ω-转氨酶催化的以异丙胺为氨基供体的非天然氨基酸的不对称合成。
ω-Transaminase-catalyzed asymmetric synthesis of unnatural amino acids using isopropylamine as an amino donor.
机构信息
Department of Biotechnology, Yonsei University, 262 Seongsanno, Seodaemun-Gu, 120-749 Seoul, South Korea.
出版信息
Org Biomol Chem. 2013 Sep 25;11(40):6929-33. doi: 10.1039/c3ob40495a.
PMID:23897436
Abstract
Isopropylamine is an ideal amino donor for reductive amination of carbonyl compounds by ω-transaminase (ω-TA) owing to its cheapness and high volatility of a ketone product. Here we developed asymmetric synthesis of unnatural amino acids via ω-TA-catalyzed amino group transfer between α-keto acids and isopropylamine.
摘要
异丙胺由于其廉价和酮产物的高挥发性，是ω-转氨酶（ω-TA）用于羰基化合物还原胺化的理想氨基供体。在这里，我们通过 ω-TA 催化的α-酮酸和异丙胺之间的氨基转移反应，开发了非天然氨基酸的不对称合成方法。
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