比较尿肌酐与其他生物标志物在检测镉诱导睾丸损伤中的应用。
Comparison of urinary creatine with other biomarkers for detection of cadmium induced testicular damage.
出版信息
Biomarkers. 1998;3(4-5):335-46. doi: 10.1080/135475098231147.
In this study, biomarkers of testicular damage were compared. In particular, urinary creatine was evaluated as a non-invasive marker of damage. Male rats were exposed to various doses of cadmium chloride, an established testicular toxicant. Pathological damage, testes weights, urinary creatine and creatinine, serum LDH-C4 and serum testosterone were determined. Cadmium chloride caused dose-dependent damage to the testes undetectable at the lowest dose (0.75 mg kg-1) but apparent at a dose of 1.125 mg kg-1. Urinary creatine was significantly raised after doses of 1.125 mg kg-1 and above 24-48 hr after dosing, and at the highest dose within 24 hr after dosing. Testes weight and serum testosterone were significantly decreased, and LDH-C4 significantly increased, at the highest dose (3.0 mg kg-l). Therefore urinary creatine was the most sensitive marker of acute cadmium-induced testicular damage and dysfunction.
在这项研究中，比较了睾丸损伤的生物标志物。特别是，尿肌酐被评估为一种非侵入性的损伤标志物。雄性大鼠暴露于不同剂量的氯化镉，这是一种已建立的睾丸毒物。测定了病理性损伤、睾丸重量、尿肌酐和肌酐、血清 LDH-C4 和血清睾酮。氯化镉引起睾丸损伤，在最低剂量（0.75 mg kg-1）下无法检测到，但在 1.125 mg kg-1 剂量下明显。在 1.125 mg kg-1 及以上剂量后 24-48 小时，以及在最高剂量后 24 小时内，尿肌酐显著升高。在最高剂量（3.0 mg kg-l）时，睾丸重量和血清睾酮显著降低，LDH-C4 显著升高。因此，尿肌酐是急性镉诱导的睾丸损伤和功能障碍最敏感的标志物。
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