神经性厌食症青少年体重恢复后正常的灰质和白质体积。
Normal gray and white matter volume after weight restoration in adolescents with anorexia nervosa.
机构信息
Department of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clínic Universitari, Barcelona, Spain; IDIBAPS (Institut d'Investigacions Biomèdiques August Pi i Sunyer), Barcelona, Spain; Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain.
出版信息
Int J Eat Disord. 2013 Dec;46(8):841-8. doi: 10.1002/eat.22161. Epub 2013 Jul 31.
OBJECTIVE
The aim of this study was to determine whether treated, weight-stabilized adolescents with anorexia nervosa (AN) present brain volume differences in comparison with healthy controls.
METHOD
Thirty-five adolescents with weight-recovered AN and 17 healthy controls were assessed by means of psychopathology scales and magnetic resonance imaging. Axial three-dimensional T1-weighted images were obtained in a 1.5 Tesla scanner and analyzed using optimized voxel-based morphometry (VBM).
RESULTS
There were no significant differences between controls and weight-stabilized AN patients with regard to global volumes of either gray or white brain matter, or in the regional VBM study. Differences were not significant between patients with psychopharmacological treatment and without, between those with amenorrhea and without, as well as between patients with restrictive versus purgative AN.
DISCUSSION
The present findings reveal no global or regional gray or white matter abnormalities in this sample of adolescents following weight restoration.
目的
本研究旨在确定治疗后体重稳定的神经性厌食症（AN）青少年与健康对照组相比是否存在脑容量差异。
方法
对 35 名体重恢复的 AN 青少年和 17 名健康对照组进行了精神病学量表评估和磁共振成像。在 1.5T 扫描仪中获得轴向三维 T1 加权图像，并使用优化的体素形态计量学（VBM）进行分析。
结果
对照组和体重稳定的 AN 患者在灰质或白质的整体体积，或在局部 VBM 研究方面均无显著差异。在接受精神药理学治疗和未接受治疗的患者之间，在闭经和无闭经的患者之间，以及在限制型与泻体型 AN 的患者之间，差异均不显著。
讨论
本研究结果显示，在体重恢复后，该样本青少年中未发现整体或局部灰质或白质异常。
Zotero 插件