Karras S N, Anagnostis P, Bili E, Naughton D, Petroczi A, Papadopoulou F, Goulis D G
Unit of Reproductive Endocrinology, First Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece,
Osteoporos Int. 2014 Mar;25(3):795-805. doi: 10.1007/s00198-013-2468-5. Epub 2013 Aug 2.
Data from animal and human studies implicate maternal vitamin D deficiency during pregnancy as a significant risk factor for several adverse outcomes affecting maternal, fetal, and child health. The possible associations of maternal vitamin D status and offspring bone development comprise a significant public health issue. Evidence from randomized trials regarding maternal vitamin D supplementation for optimization of offspring bone mass is lacking. In the same field, data from observational studies suggest that vitamin D supplementation is not indicated. Conversely, supplementation studies provided evidence that vitamin D has beneficial effects on neonatal calcium homeostasis. Nevertheless, a series of issues, such as technical difficulties of current vitamin D assays and functional interplay among vitamin D analytes, prohibit arrival at safe conclusions. Future studies would benefit from adoption of a gold standard assay, which would unravel the functions of vitamin D analytes. This narrative review summarizes and discusses data from both observational and supplementation studies regarding maternal vitamin D status during pregnancy and offspring bone development.
来自动物和人体研究的数据表明，孕期母亲维生素D缺乏是影响母亲、胎儿和儿童健康的多种不良后果的重要风险因素。母亲维生素D状态与后代骨骼发育之间的可能关联构成了一个重大的公共卫生问题。缺乏关于母亲补充维生素D以优化后代骨量的随机试验证据。在同一领域，观察性研究的数据表明无需补充维生素D。相反，补充研究提供的证据表明，维生素D对新生儿钙稳态有有益影响。然而，一系列问题，如当前维生素D检测的技术难题以及维生素D分析物之间的功能相互作用，阻碍了得出可靠结论。未来的研究将受益于采用金标准检测方法，这将揭示维生素D分析物的功能。本叙述性综述总结并讨论了来自观察性研究和补充研究的关于孕期母亲维生素D状态与后代骨骼发育的数据。
