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用于多巴胺检测的超纳米晶金刚石微传感器的特性研究

Characterization of ultrananocrystalline diamond microsensors for dopamine detection.

作者信息

Arumugam Prabhu U, Zeng Hongjun, Siddiqui Shabnam, Covey Dan P, Carlisle John A, Garris Paul A

机构信息

Advanced Diamond Technologies, Inc., 48 E Belmont Drive, Romeoville, Illinois 60446, USA.

出版信息

Appl Phys Lett. 2013 Jun 24;102(25):253107. doi: 10.1063/1.4811785. Epub 2013 Jun 28.

Abstract

We show the technical feasibility of coating and micro patterning boron-doped ultrananocrystalline diamond (UNCD) on metal microwires and of applying them as microsensors for the detection of dopamine using fast-scan cyclic voltammetry. UNCD electrode surface consistently generated electrochemical signals with high signal-to-noise ratio of >800 using potassium ferrocyanide-ferricyanide redox couple. Parylene patterned UNCD microelectrodes were effectively applied to detect dopamine reliably using flow injection analysis with a detection limit of 27 nM and in the striatum of the anesthetized rat during electrical stimulation of dopamine neurons.

摘要

我们展示了在金属微丝上涂覆和微图案化硼掺杂超纳米晶金刚石(UNCD)以及将其用作微传感器以通过快速扫描循环伏安法检测多巴胺的技术可行性。使用亚铁氰化钾 - 铁氰化钾氧化还原对,UNCD电极表面始终产生信噪比>800的高电化学信号。聚对二甲苯图案化的UNCD微电极通过流动注射分析有效地用于可靠地检测多巴胺,检测限为27 nM,并且在麻醉大鼠的纹状体中多巴胺神经元电刺激期间也可进行检测。

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