Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.
PLoS One. 2013 Aug 5;8(8):e70343. doi: 10.1371/journal.pone.0070343. Print 2013.
The suitability of different gelling agents as MRI phantoms was evaluated in terms of homogeneity, gel stability and reproducibility. Time and effort for preparation were also taken into account. The relaxation times of various gel compositions were estimated. Carbomer-980 and Carbopol-974P were determined to be promising novel phantom materials. These gelling agents are readily available, inexpensive and easy to handle given that thermal treatment is not required. Furthermore, the viscoelasticity of their polymer network is pH-dependent. With such characteristics, it was even possible to embed sensitive objects and retrieve them after testing. This was demonstrated with a fiber phantom for Diffusion Weighted MRI applications. Since Carbomer-980 and Carbopol-974P are non-hazardous, they are also suitable for multimodal setups (e.g., MRI as well as ultrasonic imaging).
评估了不同的凝胶剂作为 MRI 造影剂的适用性，主要从均匀性、凝胶稳定性和重现性方面进行了评估。同时也考虑了制备的时间和难度。测量了各种凝胶组成物的弛豫时间。卡波姆-980 和 Carbopol-974P 被确定为有前途的新型造影剂材料。这些凝胶剂很容易获得，价格低廉，而且易于操作，因为不需要热处理。此外，其聚合物网络的粘弹性取决于 pH 值。具有这些特性，甚至可以在测试后嵌入敏感物体并进行检索。这通过用于扩散加权 MRI 应用的纤维造影剂进行了证明。由于卡波姆-980 和 Carbopol-974P 是无危险的，因此它们也适用于多模态设置（例如，MRI 以及超声成像）。
