纳米颗粒模拟病毒表面形貌以增强细胞递送。
Nanoparticles mimicking viral surface topography for enhanced cellular delivery.
机构信息
Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Queensland, QLD, 4072, Australia.
出版信息
Adv Mater. 2013 Nov 20;25(43):6233-7. doi: 10.1002/adma.201302737. Epub 2013 Aug 15.
PMID:23946251
Abstract
Novel silica nanoparticles mimicking virus surface topography are prepared. It is demonstrated that increases in nanoscale surface roughness promote both binding of biomolecules and cellular uptake; thus, the cellular delivery efficiency is significantly increased (scale bars 20 μm).
摘要
新型模仿病毒表面形貌的硅纳米颗粒被制备出来。研究表明，纳米级表面粗糙度的增加促进了生物分子的结合和细胞摄取；因此，细胞递送效率显著提高（标尺 20μm）。
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