昼夜节律在钾稳态中的作用。
Role of circadian rhythms in potassium homeostasis.
机构信息
Department of Medicine, Division of Nephrology, Hypertension and Renal Transplantation, University of Florida, Gainesville, FL, USA.
出版信息
Semin Nephrol. 2013 May;33(3):229-36. doi: 10.1016/j.semnephrol.2013.04.003.
It has been known for decades that urinary potassium excretion varies with a circadian pattern. In this review, we consider the historical evidence for this phenomenon and present an overview of recent developments in the field. Extensive evidence from the latter part of the past century clearly shows that circadian potassium excretion does not depend on endogenous aldosterone. Of note is the recent discovery that the expression of several renal potassium transporters varies with a circadian pattern that appears to be consistent with substantial clinical data regarding daily fluctuations in urinary potassium levels. We propose the circadian clock mechanism as a key regulator of renal potassium transporters, and consequently renal potassium excretion. Further investigation into the regulation mechanism of renal potassium transport by the circadian clock is warranted to increase our understanding of the clinical relevance of circadian rhythms to potassium homeostasis.
几十年来，人们已经知道尿钾排泄随昼夜节律变化而变化。在这篇综述中，我们回顾了这一现象的历史证据，并概述了该领域的最新进展。上个世纪后半叶的大量证据清楚地表明，昼夜节律性钾排泄不依赖于内源性醛固酮。值得注意的是，最近的发现表明，几种肾脏钾转运体的表达随昼夜节律变化，这似乎与关于尿钾水平日常波动的大量临床数据一致。我们提出昼夜节律钟机制作为肾脏钾转运体的关键调节剂，进而作为肾脏钾排泄的关键调节剂。有必要进一步研究昼夜节律钟对肾脏钾转运的调节机制，以增加我们对昼夜节律对钾稳态的临床相关性的理解。
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