Al Hulami Hassan, Babay Nadir, Awartani Fatin, Anil Sukumaran
Al Hassa Dental Center, Hofuf, Saudi Arabia.
Saudi Dent J. 2011 Jul;23(3):143-8. doi: 10.1016/j.sdentj.2011.04.001. Epub 2011 May 3.
Locally delivered doxycycline is found to be effective in managing periodontitis as an adjunct to scaling and root planing.
To evaluate the effect of locally delivered doxycycline (10%) with scaling and root planing in the periodontal treatment of smokers and to compare it with scaling and root planing alone.
Twelve smokers with chronic periodontitis and a pocket depth (⩾5 mm) on posterior teeth that bleed on probing were selected. Patients were randomly assigned to scaling and root planing (SRP) or scaling and root planing followed by local application of doxycycline (SRP-D). Plaque, bleeding on probing, gingival recession, clinical attachment level (CAL), and probing depth (PD) were recorded at the baseline, 6 and 12 weeks.
Both groups showed a significant reduction in Plaque, Bleeding on Probing and pocket depth at 6th and 12th week from the baseline. A statistically significant gain of attachment was observed in both groups after treatment. Even though the doxycycline group showed slightly higher attachment gain it was not statistically significant compared to the control group.
The observations of the study reveal that the additional benefit of topical application of doxycycline as an adjunct to scaling and root planing in smokers is not convincing. However, further clinical studies may be necessary to substantiate the present observations.
局部应用强力霉素作为龈下刮治和根面平整术的辅助治疗手段，被发现对治疗牙周炎有效。
评估局部应用10%强力霉素联合龈下刮治和根面平整术在吸烟患者牙周治疗中的效果，并与单纯龈下刮治和根面平整术进行比较。
选取12名患有慢性牙周炎且后牙牙周袋深度≥5mm且探诊出血的吸烟者。患者被随机分配至龈下刮治和根面平整术组（SRP）或龈下刮治和根面平整术后局部应用强力霉素组（SRP-D）。在基线、6周和12周时记录菌斑、探诊出血、牙龈退缩、临床附着水平（CAL）和探诊深度（PD）。
两组在第6周和第12周时，与基线相比，菌斑、探诊出血和牙周袋深度均显著降低。治疗后两组均观察到有统计学意义的附着增加。尽管强力霉素组显示出稍高的附着增加，但与对照组相比无统计学意义。
该研究的观察结果表明，在吸烟患者中，局部应用强力霉素作为龈下刮治和根面平整术的辅助治疗手段，其额外益处并不令人信服。然而，可能需要进一步的临床研究来证实目前的观察结果。
