Markos A R, Dinsmore Wallace
HIV and Sexual Medicine, Mid Staffordshire NHS Foundation Trust, Stafford Hospital, Stafford, UK.
Int J STD AIDS. 2013 Nov;24(11):852-8. doi: 10.1177/0956462413489276. Epub 2013 Aug 1.
We conducted a literature review of patients' conditions described under persistent genital arousal disorder and restless genital syndrome, vulvodynia and male genital skin pain of unknown aetiology (penoscrotodynia). Our aim is to improve the understanding of the condition, unify nomenclature and promote evidence-based practice. The most prominent symptom in persistent genital arousal disorder and restless genital syndrome is a spontaneous, unwelcomed, intrusive and distressing vulval sensation. There are similarities between the clinical presentation of vulvodynia, penoscrotodynia, persistent genital arousal disorder and restless genital syndrome patients. The aetiology of persistent genital arousal disorder and restless genital syndrome, similar to vulvodynia, could be better explained in terms of neuro-vascular dysfunction, genital peripheral neuropathy and/or dysfunctional micro-vascular arterio-venous shunting. Erythromelalgia lends itself to explain some cases of restless genital syndrome, who have concurrent restless legs syndrome; and therefore draw parallels with the red scrotum syndrome. The published literature supports the concept of classifying restless genital syndrome as a sub-type of vulvodynia rather than sexual dysfunction.
我们对持续性性唤起障碍、不安性生殖器综合征、外阴痛以及病因不明的男性生殖器皮肤疼痛（阴茎阴囊痛）所描述的患者病情进行了文献综述。我们的目的是增进对该病症的理解，统一命名并推广循证医学实践。持续性性唤起障碍和不安性生殖器综合征最突出的症状是一种自发的、不受欢迎的、侵扰性且令人痛苦的外阴感觉。外阴痛、阴茎阴囊痛、持续性性唤起障碍和不安性生殖器综合征患者的临床表现存在相似之处。持续性性唤起障碍和不安性生殖器综合征的病因，类似于外阴痛，从神经血管功能障碍、生殖器周围神经病变和/或功能性微血管动静脉分流方面可能能得到更好的解释。红斑性肢痛症有助于解释一些伴有不安腿综合征的不安性生殖器综合征病例；因此可与红阴囊综合征相类比。已发表的文献支持将不安性生殖器综合征归类为外阴痛的一种亚型而非性功能障碍的观点。
