Parnassia Groep, PsyQ, Department of Mood Disorders and Chronobiology, Lijnbaan 4, The Hague, the Netherlands.
J Affect Disord. 2013 Dec;151(3):1135-7. doi: 10.1016/j.jad.2013.07.017. Epub 2013 Aug 7.
There is growing interest in the possible applications of Bright Light Therapy (BLT). BLT might be a valid alternative or add-on treatment for many other psychiatric disorders beyond seasonal affective disorder. This pilot study aims to examine whether the efficacy of Bright Light Therapy (BLT) is similar for different subtypes of mood disorders.
Participants were 48 newly admitted outpatients with major depressive disorder with either melancholic features (n=20) or atypical features (n=28). Morning BLT was administered daily for 30 min at 5.000-10.000 lx on working days for up to 3 consecutive weeks.
Participants' depressive symptoms improved significantly after BLT (p<.05, d=-.53). The effects of BLT remained stable across a 4 week follow-up. There were no significant differences in efficacy of BLT between groups (p>.05). No effect of seasonality on the improvement in depressive symptoms after BLT was found, (p=.781).
The study had a small sample size and lacked a control condition.
This pilot study provides preliminary evidence that BLT could be a promising treatment for depression, regardless of the melancholic or atypical character of the depressive symptoms.
人们对明亮光疗 (BLT) 的可能应用越来越感兴趣。BLT 可能是除季节性情感障碍以外的许多其他精神疾病的有效替代或附加治疗方法。这项初步研究旨在探讨 BLT 对不同类型的心境障碍的疗效是否相似。
48 名新入院的伴有忧郁特征（n=20）或非典型特征（n=28）的重性抑郁障碍患者参加了研究。在工作日期间，每天上午给予 5,000-10,000 lx 的 BLT，时长 30 分钟，连续进行 3 周。
BLT 后，参与者的抑郁症状显著改善（p<.05，d=-.53）。BLT 的效果在 4 周的随访中保持稳定。BLT 的疗效在两组之间没有显著差异（p>.05）。BLT 后抑郁症状的改善与季节性无关，（p=.781）。
该研究样本量较小，缺乏对照条件。
这项初步研究提供了初步证据，表明 BLT 可能是一种有前途的治疗抑郁症的方法，无论抑郁症状是否具有忧郁或非典型特征。
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