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布比卡因中加入利多卡因用于脊髓麻醉与布比卡因脊髓麻醉和局部浸润麻醉的比较。

Addition of lidocaine to bupivacaine for spinal anaesthesia compared with bupivacaine spinal anaesthesia and local infiltration anaesthesia.

机构信息

Anaesthiology and Reanimation, Diskapi Yildirim Beyazit Teaching and Research Hospital, Ankara, Turkey.

出版信息

Acta Anaesthesiol Scand. 2013 Nov;57(10):1313-20. doi: 10.1111/aas.12175. Epub 2013 Aug 27.

Abstract

BACKGROUND

Two spinal anaesthesia techniques were compared with local infiltration anaesthesia (LIA) to test the hypothesis that the addition of lidocaine to bupivacaine would decrease the spinal block's duration and provide shorter recovery to discharge.

METHODS

Ninety-three patients undergoing outpatient herniorrhaphy were randomised into three groups. Spinal anaesthesia: the BL Group (bupivacaine-lidocaine) received 2 ml hyperbaric bupivacaine (10 mg) + 0.6 ml 1% lidocaine (6 mg), the BS Group (bupivacaine-saline) received 2 ml hyperbaric bupivacaine (10 mg) + 0.6 ml saline. LIA: the LIA group received plain bupivacaine + lidocaine. Resolution of the nerve blocks were compared between spinal anaesthesia groups, and post-operative pain scores, analgesic requirements, post-anaesthesia care unit (PACU) time, and discharge time were compared among all groups.

RESULTS

Spinal block resolved faster in the BL group vs. the BS group: 194.8 [standard deviation (SD) 29.2] min vs. 236.8 (SD 36.5) min (P = 0.000). PACU and discharge time were shortest in the LIA group [PACU time: 108.7 (SD 27.6) min vs. 113.0 (SD 39.4) min and 151.9 (SD 43.7) min in the BL and BS groups (P = 0.000), and discharge time 108.5 (SD 29.5) min vs. 145.8 (SD 37.3) min and 177.1 (SD 32.0) min in the BL and BS groups, respectively (P = 0.000)]. Pain scores and analgesic consumption were lower, with the time to first analgesic intake being longer in the LIA group.

CONCLUSION

Addition of lidocaine to bupivacaine reduced the duration of the spinal block and was associated with shorter recovery times. However, LIA provided the fastest recovery to discharge after outpatient inguinal herniorrhaphy.

摘要

背景

本研究比较了两种椎管内麻醉技术与局部浸润麻醉(LIA),旨在验证在布比卡因中加入利多卡因是否会缩短椎管内阻滞的持续时间,并缩短术后恢复出院时间的假设。

方法

本研究纳入 93 例行门诊疝修补术的患者,随机分为三组。椎管内麻醉:BL 组(布比卡因-利多卡因)接受 2ml 重比重布比卡因(10mg)+0.6ml 1%利多卡因(6mg),BS 组(布比卡因-生理盐水)接受 2ml 重比重布比卡因(10mg)+0.6ml 生理盐水。LIA 组:接受单纯布比卡因+利多卡因。比较椎管内麻醉组之间的神经阻滞消退情况,比较所有组之间的术后疼痛评分、镇痛需求、麻醉后监护室(PACU)时间和出院时间。

结果

BL 组的椎管内阻滞消退速度快于 BS 组:194.8[标准差(SD)29.2]min vs. 236.8(SD 36.5)min(P=0.000)。LIA 组的 PACU 和出院时间最短:PACU 时间分别为 108.7(SD 27.6)min、113.0(SD 39.4)min 和 151.9(SD 43.7)min,明显短于 BL 组和 BS 组(P=0.000);出院时间分别为 108.5(SD 29.5)min、145.8(SD 37.3)min 和 177.1(SD 32.0)min,明显短于 BL 组和 BS 组(P=0.000)。LIA 组疼痛评分和镇痛药物消耗较低,首次使用镇痛药物的时间也较长。

结论

在布比卡因中加入利多卡因缩短了椎管内阻滞的持续时间,与恢复时间缩短相关。然而,LIA 可使门诊腹股沟疝修补术后最快恢复出院。

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