Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, USA; The Center for Cell Cycle Analysis, Longboat Key, FL, USA.
FEMS Yeast Res. 2013 Nov;13(7):650-8. doi: 10.1111/1567-1364.12072. Epub 2013 Sep 23.
Length measurements during the division cycle of 86 individual Schizosaccharomyces pombe cells demonstrate that length grows exponentially with no change in the growth rate and no rate change point (RCP) observed for any cell. These results support the proposal that length extension, or cell growth, is exponential during the division cycle. The finding of exponential growth during the cell cycle is significant because these results challenge and contradict the current, consensus, widely believed, and widely accepted view that growth of S. pombe during the division cycle is complex with ranges of linear growth changing at proposed RCPs. Biochemical synthetic patterns support and explain the observed exponential cell growth. Exponential growth of S. pombe is consistent with, and supports, the central tenets of the continuum model.
86 个单个裂殖酵母细胞分裂周期中的长度测量表明,长度呈指数增长,没有观察到任何细胞的生长速率变化或速率变化点 (RCP)。这些结果支持了这样的假设,即在细胞分裂周期中,长度的延伸或细胞生长是指数增长的。在细胞周期中发现指数生长是重要的,因为这些结果挑战和反驳了当前的共识观点,即广泛认为和广泛接受的观点,即裂殖酵母在细胞分裂周期中的生长是复杂的,线性生长在提议的 RCP 处发生变化。生化合成模式支持并解释了观察到的指数细胞生长。裂殖酵母的指数生长与连续模型的核心原则是一致的,并为其提供支持。