心力衰竭中心脏钙离子处理改变的机制。
Mechanisms of altered Ca²⁺ handling in heart failure.
机构信息
Division of Cardiovascular Medicine, Department of Internal Medicine, Cardiovascular Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
出版信息
Circ Res. 2013 Aug 30;113(6):690-708. doi: 10.1161/CIRCRESAHA.113.301651.
Abstract
Ca²⁺ plays a crucial role in connecting membrane excitability with contraction in myocardium. The hallmark features of heart failure are mechanical dysfunction and arrhythmias; defective intracellular Ca²⁺ homeostasis is a central cause of contractile dysfunction and arrhythmias in failing myocardium. Defective Ca²⁺ homeostasis in heart failure can result from pathological alteration in the expression and activity of an increasingly understood collection of Ca²⁺ homeostatic and structural proteins, ion channels, and enzymes. This review focuses on the molecular mechanisms of defective Ca²⁺ cycling in heart failure and considers how fundamental understanding of these pathways may translate into novel and innovative therapies.
摘要
钙离子在心肌兴奋-收缩耦联中起着至关重要的作用。心力衰竭的主要特征是机械功能障碍和心律失常；细胞内钙离子稳态失调是心力衰竭心肌收缩功能障碍和心律失常的核心原因。心力衰竭时钙离子稳态失调可导致越来越多的钙离子稳态和结构蛋白、离子通道和酶的表达和活性发生病理性改变。本综述重点讨论心力衰竭时钙离子循环异常的分子机制，并探讨对这些途径的深入了解如何转化为新的创新性治疗方法。
相似文献
1
Mechanisms of altered Ca²⁺ handling in heart failure.
Circ Res. 2013 Aug 30;113(6):690-708. doi: 10.1161/CIRCRESAHA.113.301651.
2
Ca handling during excitation-contraction coupling in heart failure.
Pflugers Arch. 2014 Jun;466(6):1129-37. doi: 10.1007/s00424-014-1469-3. Epub 2014 Feb 11.
3
Mitochondrial Calcium Overload Plays a Causal Role in Oxidative Stress in the Failing Heart.
Biomolecules. 2023 Sep 19;13(9):1409. doi: 10.3390/biom13091409.
4
[Excitation-Contraction coupling and intracellular calcium cycling in failing hearts].
Clin Calcium. 2013 Apr;23(4):471-80.
5
Redox regulation of sodium and calcium handling.
Antioxid Redox Signal. 2013 Mar 20;18(9):1063-77. doi: 10.1089/ars.2012.4818. Epub 2012 Oct 3.
6
Sensitivity analysis revealing the effect of modulating ionic mechanisms on calcium dynamics in simulated human heart failure.
PLoS One. 2017 Nov 8;12(11):e0187739. doi: 10.1371/journal.pone.0187739. eCollection 2017.
7
Altered sarcoplasmic reticulum calcium cycling--targets for heart failure therapy.
Nat Rev Cardiol. 2012 Dec;9(12):717-33. doi: 10.1038/nrcardio.2012.145. Epub 2012 Oct 23.
8
New Insights in Cardiac Calcium Handling and Excitation-Contraction Coupling.
Adv Exp Med Biol. 2018;1067:373-385. doi: 10.1007/5584_2017_106.
9
Calcium cycling in heart failure: the arrhythmia connection.
J Cardiovasc Electrophysiol. 2002 Jan;13(1):88-91. doi: 10.1046/j.1540-8167.2002.00088.x.
10
Interplay of defective excitation-contraction coupling, energy starvation, and oxidative stress in heart failure.
Trends Cardiovasc Med. 2011 Apr;21(3):69-73. doi: 10.1016/j.tcm.2012.03.002.
引用本文的文献
1
Calcium signalling and organelle crosstalk in cardiovascular disease: an interplay of cardiac cell death pathways.
Mol Biol Rep. 2025 Sep 16;52(1):907. doi: 10.1007/s11033-025-10974-6.
2
Carfilzomib-specific proteasome β5/β2 inhibition drives cardiotoxicity via remodeling of protein homeostasis and the renin-angiotensin-system.
iScience. 2025 Jul 29;28(9):113228. doi: 10.1016/j.isci.2025.113228. eCollection 2025 Sep 19.
3
Tubulin tyrosine ligase variant perturbs microtubule tyrosination, causing hypertrophy in patient-specific and CRISPR gene-edited iPSC-cardiomyocytes.
JCI Insight. 2025 Aug 8;10(15). doi: 10.1172/jci.insight.187942.
4
Ultrastructure analysis of mitochondria, lipid droplet and sarcoplasmic reticulum apposition in human heart failure.
J Mol Cell Cardiol Plus. 2025 Jun 10;13:100461. doi: 10.1016/j.jmccpl.2025.100461. eCollection 2025 Sep.
5
YOD1 mediates isoproterenol-induced cardiac remodeling by deubiquitinating PKM2 and reducing PKM2 tetramerization in cardiomyocytes.
Acta Pharmacol Sin. 2025 Jun 11. doi: 10.1038/s41401-025-01587-7.
6
Emerging roles for microproteins as critical regulators of endoplasmic reticulum function and cellular homeostasis.
Semin Cell Dev Biol. 2025 Jun;170:103608. doi: 10.1016/j.semcdb.2025.103608. Epub 2025 Apr 17.
7
Human induced pluripotent stem cell-derived cardiomyocytes and their use in a cardiac organ-on-a-chip to assay electrophysiology, calcium and contractility.
Nat Protoc. 2025 Apr 7. doi: 10.1038/s41596-025-01166-4.
8
Therapeutic effects of lomerizine on vasculopathy in Fabry disease.
Sci Rep. 2025 Apr 2;15(1):11355. doi: 10.1038/s41598-025-94795-4.
9
Cardioprotective role of SIRT1 activation on mitochondrial function in insulin-resistant H9c2 cells.
BMC Cardiovasc Disord. 2025 Mar 29;25(1):232. doi: 10.1186/s12872-024-04397-7.
10
Inhibition of the Renin-Angiotensin System Improves Hemodynamic Function of the Diabetic Rat Heart by Restoring Intracellular Calcium Regulation.
Biomedicines. 2025 Mar 20;13(3):757. doi: 10.3390/biomedicines13030757.
本文引用的文献
1
Diabetes increases mortality after myocardial infarction by oxidizing CaMKII.
J Clin Invest. 2013 Mar;123(3):1262-74. doi: 10.1172/JCI65268. Epub 2013 Feb 15.
2
Epac2 mediates cardiac β1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia.
Circulation. 2013 Feb 26;127(8):913-22. doi: 10.1161/CIRCULATIONAHA.12.148619. Epub 2013 Jan 30.
3
In vivo suppression of microRNA-24 prevents the transition toward decompensated hypertrophy in aortic-constricted mice.
Circ Res. 2013 Feb 15;112(4):601-5. doi: 10.1161/CIRCRESAHA.112.300806. Epub 2013 Jan 10.
4
Crucial role for Ca2(+)/calmodulin-dependent protein kinase-II in regulating diastolic stress of normal and failing hearts via titin phosphorylation.
Circ Res. 2013 Feb 15;112(4):664-74. doi: 10.1161/CIRCRESAHA.111.300105. Epub 2013 Jan 2.
5
Inhibition of CaMKII phosphorylation of RyR2 prevents inducible ventricular arrhythmias in mice with Duchenne muscular dystrophy.
Heart Rhythm. 2013 Apr;10(4):592-9. doi: 10.1016/j.hrthm.2012.12.016. Epub 2012 Dec 12.
6
Regulation of cardiac ATP-sensitive potassium channel surface expression by calcium/calmodulin-dependent protein kinase II.
J Biol Chem. 2013 Jan 18;288(3):1568-81. doi: 10.1074/jbc.M112.429548. Epub 2012 Dec 6.
7
MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism.
Nat Cell Biol. 2012 Dec;14(12):1336-43. doi: 10.1038/ncb2622. Epub 2012 Nov 25.
8
Cardiotoxic and cardioprotective features of chronic β-adrenergic signaling.
Circ Res. 2013 Feb 1;112(3):498-509. doi: 10.1161/CIRCRESAHA.112.273896. Epub 2012 Oct 25.
9
MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival.
Cell. 2012 Oct 26;151(3):630-44. doi: 10.1016/j.cell.2012.10.011.
10
New therapeutic targets in cardiology: arrhythmias and Ca2+/calmodulin-dependent kinase II (CaMKII).
Circulation. 2012 Oct 23;126(17):2125-39. doi: 10.1161/CIRCULATIONAHA.112.124990.
Zotero 插件