Jiang Haitao, Lian Minxue, Xie Jiangtao, Li Jinzheng, Wang Maode
Department of Neurosurgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.
J Int Med Res. 2013 Oct;41(5):1484-94. doi: 10.1177/0300060513498667. Epub 2013 Sep 5.
To investigate the association between three single nucleotide polymorphisms (SNPs) of the vascular endothelial growth factor (VEGF) gene and the risk of glioma in a Han Chinese population.
This hospital-based case-control study used polymerase chain reaction-restriction fragment length polymorphism analysis to detect three SNPs (-634 G/C, +936 C/T and +1612 G/A) of the VEGF gene in patients with glioma compared with healthy control subjects.
The study investigated 880 patients with gliomas and 880 age- and sex-matched healthy control subjects. Patients with gliomas had a significantly higher frequency of the -634 CC genotype (odds ratio [OR] 1.35, 95% confidence interval [CI] 1.05, 1.75) and the +936 TT (OR 1.73, 95% CI 1.20, 2.48) genotype compared with the control subjects. Patients with glioblastomas had a significantly higher frequency of the -634 CC and +936 TT genotypes. Patients with grade IV gliomas had a significantly higher frequency of the -634 CC and +936 TT genotypes. The +1612 G/A polymorphisms were not associated with glioma risk.
The VEGF - 634 CC and +936 TT genotypes were associated with a higher risk of glioma in a Han Chinese population.
探讨血管内皮生长因子（VEGF）基因的三个单核苷酸多态性（SNP）与汉族人群患胶质瘤风险之间的关联。
本基于医院的病例对照研究采用聚合酶链反应-限制性片段长度多态性分析，检测胶质瘤患者与健康对照者中VEGF基因的三个SNP（-634G/C、+936C/T和+1612G/A）。
该研究调查了880例胶质瘤患者和880例年龄及性别匹配的健康对照者。与对照者相比，胶质瘤患者中-634CC基因型（优势比[OR]1.35，95%置信区间[CI]1.05，1.75）和+936TT（OR 1.73，95%CI 1.20，2.48）基因型的频率显著更高。胶质母细胞瘤患者中-634CC和+936TT基因型的频率显著更高。IV级胶质瘤患者中-634CC和+936TT基因型的频率显著更高。+1612G/A多态性与胶质瘤风险无关。
在汉族人群中，VEGF -634CC和+936TT基因型与患胶质瘤的较高风险相关。
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