莫沙必利对健康志愿者食管运动活性及食管胃交界部顺应性的影响。
Effects of mosapride on esophageal motor activity and esophagogastric junction compliance in healthy volunteers.
作者信息
Fukazawa Kousuke, Furuta Kenji, Adachi Kyoichi, Moritou Yoshiya, Saito Tsukasa, Kusunoki Ryusaku, Uno Goichi, Shimura Shino, Aimi Masahito, Ohara Shunji, Ishihara Shunji, Kinoshita Yoshikazu
机构信息
Second Department of Internal Medicine, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo, Shimane, 693-8501, Japan,
出版信息
J Gastroenterol. 2014 Sep;49(9):1307-13. doi: 10.1007/s00535-013-0876-0. Epub 2013 Sep 7.
BACKGROUND
The effects of the prokinetic drug mosapride on esophageal motor activity vary at standard doses. In addition to esophageal motor activities, compliance of the esophagogastric junction (EGJ) is important for prevention of gastroesophageal reflux. However, the effects of mosapride on EGJ compliance have not been reported. Here, we investigated the effects of high-dose mosapride on esophageal motor activities and EGJ compliance.
METHODS
Nine healthy volunteers were enrolled in the study. Peristaltic esophageal contraction and lower esophageal sphincter pressures before and after administration of 40 mg mosapride were examined by high resolution esophageal manometry. Esophageal compliance was also investigated by intra-esophageal impedance planimetry (EndoFLIP(®)).
RESULTS
High-dose mosapride augmented peristaltic contractions, especially in the distal esophageal segments (P < 0.05). The mean resting lower esophageal sphincter pressure was elevated from 25.0 mmHg before administration to 28.9 mmHg after (P < 0.05). In addition, mosapride significantly reduced EGJ compliance (P < 0.05).
CONCLUSIONS
Mosapride at 40 mg augmented esophageal motor activities and reduced EGJ compliance in healthy volunteers.
背景
促动力药物莫沙必利在标准剂量下对食管运动活性的影响存在差异。除食管运动活性外，食管胃交界处（EGJ）的顺应性对于预防胃食管反流也很重要。然而，莫沙必利对EGJ顺应性的影响尚未见报道。在此，我们研究了高剂量莫沙必利对食管运动活性和EGJ顺应性的影响。
方法
9名健康志愿者参与本研究。通过高分辨率食管测压法检测40mg莫沙必利给药前后的食管蠕动收缩和食管下括约肌压力。还通过食管内阻抗平面测量法（EndoFLIP®）研究食管顺应性。
结果
高剂量莫沙必利增强了蠕动收缩，尤其是在食管远端节段（P<0.05）。食管下括约肌平均静息压力从给药前的25.0mmHg升高至给药后的28.9mmHg（P<0.05）。此外，莫沙必利显著降低了EGJ顺应性（P<0.05）。
结论
40mg莫沙必利增强了健康志愿者的食管运动活性并降低了EGJ顺应性。
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