Department of Acute Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
PLoS One. 2013 Sep 4;8(9):e70977. doi: 10.1371/journal.pone.0070977. eCollection 2013.
To determine whether the introduction of the Universal Form of Treatment Options (the UFTO), as an alternative approach to Do Not Attempt Cardiopulmonary Resuscitation (DNACPR) orders, reduces harms in patients in whom a decision not to attempt cardiopulmonary resuscitation (CPR) was made, and to understand the mechanism for any observed change.
A mixed-methods before-and-after study with contemporaneous case controls was conducted in an acute hospital. We examined DNACPR (103 patients with DNACPR orders in 530 admissions) and UFTO (118 decisions not to attempt resuscitation in 560 admissions) practice. The Global Trigger Tool was used to quantify harms. Qualitative interviews and observations were used to understand mechanisms and effects.
RATE OF HARMS IN PATIENTS FOR WHOM THERE WAS A DOCUMENTED DECISION NOT TO ATTEMPT CPR WAS REDUCED: Rate difference per 1000 patient-days was 12.9 (95% CI: 2.6-23.2, p-value=0.01). There was a difference in the proportion of harms contributing to patient death in the two periods (23/71 in the DNACPR period to 4/44 in the UFTO period (95% CI 7.8-36.1, p-value=0.006). Significant differences were maintained after adjustment for known confounders. No significant change was seen on contemporaneous case control wards. Interviews with clinicians and observation of ward practice revealed the UFTO helped provide clarity of goals of care and reduced negative associations with resuscitation decisions.
Introducing the UFTO was associated with a significant reduction in harmful events in patients in whom a decision not to attempt CPR had been made. Coupled with supportive qualitative evidence, this indicates the UFTO improved care for this vulnerable group.
Controlled-Trials.com ISRCTN85474986 UK Comprehensive Research Network Portfolio 7932.
确定通用治疗选择表(UFTO)作为非心肺复苏(DNACPR)医嘱的替代方法,是否降低了已决定不尝试心肺复苏(CPR)患者的伤害,并了解观察到的变化的机制。
在一家急性医院进行了一项混合方法的前后对照研究,同时纳入了病例对照。我们检查了 DNACPR(530 次入院中有 103 例患者有 DNACPR 医嘱)和 UFTO(560 次入院中有 118 例未尝试复苏的决策)实践。使用全球触发工具来量化伤害。定性访谈和观察用于了解机制和效果。
有明确不尝试 CPR 决策的患者的伤害发生率降低:每 1000 个患者-天的差异率为 12.9(95%CI:2.6-23.2,p 值=0.01)。两个时期的患者死亡相关伤害比例存在差异(DNACPR 时期为 23/71,UFTO 时期为 4/44(95%CI 7.8-36.1,p 值=0.006))。在调整了已知混杂因素后,差异仍然存在。同期病例对照病房没有观察到显著变化。对临床医生的访谈和对病房实践的观察表明,UFTO 有助于明确患者的治疗目标,并减少与复苏决策相关的负面联想。
引入 UFTO 与已决定不尝试 CPR 的患者的有害事件发生率显著降低相关。结合支持性的定性证据,这表明 UFTO 改善了这一脆弱群体的护理。
受控试验.com ISRCTN85474986 英国综合研究网络组合 7932。