Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
PLoS One. 2013 Sep 9;8(9):e72896. doi: 10.1371/journal.pone.0072896. eCollection 2013.
Both gastric bypass (GB) and duodenal switch with sleeve gastrectomy (DS) have been widely used as bariatric surgeries, and DS appears to be superior to GB. The aim of this study was to better understand the mechanisms leading to body weight loss by comparing these two procedures in experimental models of rats.
Animals were subjected to GB, DS or laparotomy (controls), and monitored by an open-circuit indirect calorimeter composed of comprehensive laboratory animal monitoring system and adiabatic bomb calorimeter.
Body weight loss was greater after DS than GB. Food intake was reduced after DS but not GB. Energy expenditure was increased after either GB or DS. Fecal energy content was increased after DS but not GB.
GB induced body weight loss by increasing energy expenditure, whereas DS induced greater body weight loss by reducing food intake, increasing energy expenditure and causing malabsorption in rat models.
胃旁路术（GB）和袖状胃旁路术（DS）已广泛应用于减重手术，且 DS 似乎优于 GB。本研究旨在通过比较这两种方法在大鼠实验模型中的作用机制，更好地理解导致体重减轻的机制。
动物接受了 GB、DS 或剖腹术（对照组），并通过由综合实验室动物监测系统和绝热弹式量热计组成的开路间接热量计进行监测。
DS 后体重减轻大于 GB。DS 后摄食量减少，但 GB 后未减少。GB 或 DS 后能量消耗增加。DS 后粪便能量含量增加，但 GB 后未增加。
GB 通过增加能量消耗导致体重减轻，而 DS 通过减少食物摄入、增加能量消耗和引起大鼠模型中的吸收不良导致更大的体重减轻。
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