SOT 研讨会重点：睾丸毒性的可转化指标：抑制素 B、microRNAs 和精子特征。
SOT Symposium Highlight: Translatable Indicators of Testicular Toxicity: Inhibin B, MicroRNAs, and Sperm Signatures.
机构信息
* Division of Urology, Rhode Island Hospital, Providence, Rhode Island 02903;
出版信息
Toxicol Sci. 2013 Dec;136(2):265-73. doi: 10.1093/toxsci/kft207. Epub 2013 Sep 19.
Testicular toxicity is an important safety endpoint in drug development and risk assessment, but reliable and translatable biomarkers for predicting injury have eluded researchers. However, this area shows great potential for improvement, with several avenues currently being pursued. This was the topic of a symposium session during the 2013 Society of Toxicology Annual Meeting in San Antonio, TX, entitled "Translatable Indicators of Testicular Toxicity: Inhibin B, MicroRNAs, and Sperm Signatures." This symposium brought together stakeholders from academia, government, and industry to present the limitations and drawbacks of currently used indicators of injury and discussed the ongoing efforts in developing more predictive biomarkers of injury. The presentations highlighted the early challenges of using circulating inhibin B and microRNA levels, and sperm messenger RNA transcript abundance and DNA methylation profiles, as novel biomarkers of testicular toxicity.
睾丸毒性是药物开发和风险评估中的一个重要安全终点，但可靠且可转化的生物标志物来预测损伤一直困扰着研究人员。然而，该领域具有很大的改进潜力，目前正在探索几种途径。这是在德克萨斯州圣安东尼奥举行的 2013 年毒理学学会年会上的一个研讨会专题，题为“睾丸毒性的可转化指标：抑制素 B、microRNAs 和精子特征”。该研讨会汇集了来自学术界、政府和工业界的利益相关者，介绍了目前用于损伤的指标的局限性和缺点，并讨论了开发更具预测性的损伤生物标志物的持续努力。演讲强调了使用循环抑制素 B 和 microRNA 水平以及精子信使 RNA 转录丰度和 DNA 甲基化谱作为睾丸毒性新型生物标志物的早期挑战。
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