Yu Lan, Wu Shiwu, Zhou Lei, Song Wenqing, Wang Danna
Department of Pathology, First Affiliated Hospital of Bengbu Medical College; Department of Pathology, Bengbu Medical College; Anhui Key Laboratory of Infection and Immunology, Bengbu 233030, China.E-mail:
Nan Fang Yi Ke Da Xue Xue Bao. 2013 Sep;33(9):1336-40.
To explore the expressions of CD133 and CD82/KAI1 in bladder urothelial carcinoma, their association with the clinicopathological factors and their roles in vasculogenic mimicry (VM) in the tumor.
The expressions of CD133 and CD82/KAI1 and VM were detected by immunohistochemistry and histochemistry in 90 specimens of bladder urothelial carcinoma and 20 specimens of normal bladder epithelium tissue.
The positivity rates of CD133, CD82/KAI1 and VM in normal bladder epithelium tissue were 0, 90% and 0, showing significant differences from the rates of 65.6%, 31.1% and 31.1% in urothelial carcinoma, respectively (P<0.01). Positive expressions of CD133, CD82/KAI1 and VM were significantly correlated with pTNM stage and tumor relapse (P<0.01) but not with gender, age, or tumor numbers (P>0.05). CD133 expression was positively correlated with VM (P=0.487, P<0.05), and CD82/KAI1 expression was negatively correlated with VM (r=-0.452, P<0.01) and CD133 (r=-0.776, P<0.05).
The expressions of CD133 and CD82/KAI1 proteins are involved in the occurrence of VM in bladder urothelial carcinoma to contribute to the invasion and relapse of bladder carcinoma.
探讨CD133和CD82/KAI1在膀胱尿路上皮癌中的表达情况，它们与临床病理因素的关系以及在肿瘤血管生成拟态（VM）中的作用。
采用免疫组织化学和组织化学方法检测90例膀胱尿路上皮癌标本及20例正常膀胱上皮组织标本中CD133、CD82/KAI1的表达及VM情况。
正常膀胱上皮组织中CD133、CD82/KAI1及VM的阳性率分别为0、90%和0，与尿路上皮癌中的65.6%、31.1%和31.1%相比差异有统计学意义（P<0.01）。CD133、CD82/KAI1及VM的阳性表达与pTNM分期和肿瘤复发显著相关（P<0.01），但与性别、年龄或肿瘤数量无关（P>0.05）。CD133表达与VM呈正相关（P=0.487，P<0.05），CD82/KAI1表达与VM呈负相关（r=-0.452，P<0.01），与CD133呈负相关（r=-0.776，P<0.05）。
CD133和CD82/KAI1蛋白的表达参与膀胱尿路上皮癌VM的发生，促进膀胱癌的侵袭和复发。
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