基于噬菌体T7展示文库肽的Gp10硫醚化反应（10BASE(d)-T）。
Gp10 based-thioetherification (10BASE(d)-T) on a displaying library peptide of bacteriophage T7.
作者信息
Fukunaga Keisuke, Hatanaka Takaaki, Ito Yuji, Taki Masumi
机构信息
Department of Engineering Science, Bioscience and Technology Program, The Graduate School of Informatics and Engineering, The University of Electro-Communications (UEC), 1-5-1 Chofugaoka, Chofu, Tokyo 182-8585, Japan.
出版信息
Mol Biosyst. 2013 Dec;9(12):2988-91. doi: 10.1039/c3mb70379g. Epub 2013 Sep 27.
The site-specific introduction of a haloacetamide derivative into a designated cysteine on a displaying peptide on a capsid protein (gp10) of bacteriophage T7 has been achieved. This easiest gp10-based thioetherification (10BASEd-T) is carried out in one-pot without side reactions or loss of phage infectivity.
已实现将卤代乙酰胺衍生物位点特异性引入噬菌体T7衣壳蛋白（gp10）上展示肽的指定半胱氨酸中。这种最简单的基于gp10的硫醚化反应（10BASEd-T）在一步反应中进行，没有副反应，也不会损失噬菌体的感染性。
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