载有吉西他滨和阿霉素的胶束纳米粒显示出协同作用。
Micellar nanoparticles loaded with gemcitabine and doxorubicin showed synergistic effect.
机构信息
Department of Breast Surgery, The First Affiliated Hospital of the Henan University of Science and Technology, Luoyang, Henan 471003, PR China.
Department of Breast Surgery, The First Affiliated Hospital of the Henan University of Science and Technology, Luoyang, Henan 471003, PR China.
出版信息
Colloids Surf B Biointerfaces. 2014 Jan 1;113:158-68. doi: 10.1016/j.colsurfb.2013.08.010. Epub 2013 Aug 18.
Gemcitabine and doxorubicin were separately chemically linked to biodegradable polymers to prepare polymer-gemcitabine and polymer-doxorubicin conjugates. Moreover, the two conjugates can self-assemble into micelles with both gemcitabine and doxorubicin. In this way, the two anticancer drugs were combined. The in vitro MTT assay with these combined drugs showed synergistic effect compared to single use of each drug.
阿霉素和吉西他滨分别与可生物降解聚合物化学连接，制备聚合物-吉西他滨和聚合物-阿霉素缀合物。此外，这两种缀合物可以自组装成具有吉西他滨和阿霉素的胶束。通过这种方式，两种抗癌药物结合在一起。与单独使用每种药物相比，这些联合药物的体外 MTT 测定显示出协同作用。
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