Xu Lei, Zhou Xin, Xu Lin, Yin Rong
Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital Cancer Institute of Jiangsu Province, Nanjing, China.
Tumour Biol. 2014 Feb;35(2):1661-9. doi: 10.1007/s13277-013-1229-6. Epub 2013 Oct 5.
Survivin, a member of the inhibitor of apoptosis protein family, encoded by BIRC5, is involved in the regulation of apoptosis and in cell cycle control. Emerging evidences indicate that polymorphism in BIRC5 promoter (rs9904341) is associated with cancer risk, but the results of individually published studies are inconclusive. Thus, an updated meta-analysis was performed. PubMed was searched for all eligible studies. Pooled odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated to assess the association strength. Stratified analysis was performed by cancer type, source of control, genotyping method, and ethnicity. A number of 26 studies, including 6,041 cases and 7,567 controls were analyzed in this meta-analysis. Overall, significantly increased cancer risk was associated with survivin rs9904341 polymorphism when all studies were pooled (CC vs. GG: OR = 1.36, 95 % CI = 1.09-1.69; P heterogeneity < 0.001; CC vs GC/GG: OR = 1.32, 95 % CI = 1.11-1.57; P heterogeneity < 0.001). Stratified analysis by cancer type revealed that the survivin rs9904341 polymorphism may increase the risk of colorectal cancer, renal cell cancer, gastric cancer, and bladder cancer. Further subgroup analysis by ethnicity indicated that there was a statistically increased cancer risk in Asians but not Caucasians. In this updated meta-analysis of 26 studies, we conclude that the survivin rs9904341 polymorphism might contribute to risk of various cancers, especially in Asian populations.
生存素是凋亡抑制蛋白家族的成员之一，由BIRC5编码，参与细胞凋亡调控和细胞周期控制。新出现的证据表明，BIRC5启动子多态性（rs9904341）与癌症风险相关，但个别发表研究的结果尚无定论。因此，进行了一项更新的荟萃分析。通过检索PubMed获取所有符合条件的研究。计算合并比值比（OR）和95%置信区间（CI）以评估关联强度。按癌症类型、对照来源、基因分型方法和种族进行分层分析。本荟萃分析纳入了26项研究，共6041例病例和7567例对照。总体而言，当汇总所有研究时，生存素rs9904341多态性与癌症风险显著增加相关（CC与GG：OR = 1.36，95%CI = 1.09 - 1.69；P异质性<0.001；CC与GC/GG：OR = 1.32，95%CI = 1.11 - 1.57；P异质性<0.001）。按癌症类型进行的分层分析显示，生存素rs9904341多态性可能增加结直肠癌、肾细胞癌、胃癌和膀胱癌的风险。按种族进行的进一步亚组分析表明，亚洲人癌症风险有统计学意义的增加，而高加索人则无。在这项对26项研究的更新荟萃分析中，我们得出结论，生存素rs9904341多态性可能与多种癌症的风险相关，尤其是在亚洲人群中。
