水蛭Retzius神经细胞静息钠电导率对河豚毒素的敏感性。
Sensitivity of the resting sodium conductivity of leech Retzius nerve cells to tetrodotoxin.
作者信息
Beleslin B B
出版信息
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1985;81(2):323-8. doi: 10.1016/0742-8413(85)90014-3.
Simultaneously, the effect of sodium-free medium and tetrodotoxin (3 X 10(-8) M/ml) were investigated on some passive electrophysiological properties of leech Retzius nerve cells. Complete replacement of Na+ with Tris or addition of tetrodotoxin to the leech Ringer was followed by an increase of input resistance in contrast to the cell-to-cell interaction which was not affected by such a procedure. At the same time tetrodotoxin was not able to block repetitive spike activity. The data imply the existence of two types of Na+ channel in leech Retzius nerve cells.
同时，研究了无钠培养基和河豚毒素（3×10⁻⁸ M/ml）对水蛭瑞氏神经细胞某些被动电生理特性的影响。用Tris完全替代Na⁺或向水蛭林格液中添加河豚毒素后，输入电阻增加，与此形成对比的是，这种操作并不影响细胞间的相互作用。同时，河豚毒素无法阻断重复的锋电位活动。这些数据表明水蛭瑞氏神经细胞中存在两种类型的Na⁺通道。
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