心肌闪烁显像术可能预测向路易体痴呆转化。
Myocardial scintigraphy may predict the conversion to probable dementia with Lewy bodies.
机构信息
From the Institute for Aging Brain and Cognitive Disorders (H.O., A.T., K.-i.S., Y.Y., S.O.) and Department of Radiology (K.I., R.K.), Hygo Brain and Heart Center, Himeji, Hyogo; and the Neurocognitive Disorders Center (K.I.), Kinki University Faculty of Medicine, Osakasayama, Osaka, Japan.
出版信息
Neurology. 2013 Nov 12;81(20):1741-5. doi: 10.1212/01.wnl.0000435553.67953.81. Epub 2013 Oct 11.
OBJECTIVE
To compare the usefulness of brain perfusion SPECT and (123)I-metaiodobenzylguanidine ((123)I-MIBG) in predicting the conversion of possible dementia with Lewy bodies (DLB) to probable DLB.
METHODS
We examined 94 patients with possible DLB based on the Consensus Criteria for the Clinical Diagnosis of DLB by N-Isopropyl-p-(123)I-iodoamphetamine ((123)I-IMP) brain perfusion SPECT and (123)I-MIBG myocardial scintigraphy. After 1 year of follow-up, 33 of 94 patients met the criteria for probable DLB. (123)I-IMP brain perfusion SPECT and (123)I-MIBG myocardial scintigraphy were tested as predictors of the conversion from possible DLB to probable DLB. A receiver operating characteristic (ROC) analysis was performed.
RESULTS
The areas under the ROC curves for SPECT for predicting the conversion to probable DLB from possible DLB based on the occipital/cerebellum and occipital/striatum cortex ratios of blood flow counts were 0.591 and 0.585, respectively. The areas under the ROC curves for (123)I-MIBG based on the early heart to mediastinum (H/M) ratio, delayed H/M ratio, and washout rate were 0.935, 0.936, and 0.884, respectively.
CONCLUSION
(123)I-MIBG myocardial scintigraphy is a good predictor of the future conversion of possible DLB to probable DLB.
目的
比较脑灌注单光子发射计算机断层扫描（SPECT）和碘-123 间碘苄胍（123I-MIBG）在预测可能的路易体痴呆（DLB）向可能的 DLB 转化中的作用。
方法
我们通过 N-异丙基-123I-碘代安非他命（123I-IMP）脑灌注 SPECT 和 123I-MIBG 心肌闪烁显像检查了 94 例可能的 DLB 患者。经过 1 年的随访，94 例患者中有 33 例符合可能的 DLB 的标准。（123）I-IMP 脑灌注 SPECT 和 123I-MIBG 心肌闪烁显像被用作从可能的 DLB 向可能的 DLB 转化的预测因子进行测试。进行了接收器操作特性（ROC）分析。
结果
基于血流计数的枕叶/小脑和枕叶/纹状体皮质比，SPECT 预测从可能的 DLB 向可能的 DLB 转化的 ROC 曲线下面积分别为 0.591 和 0.585。123I-MIBG 基于早期心脏与纵隔（H/M）比值、延迟 H/M 比值和洗脱率的 ROC 曲线下面积分别为 0.935、0.936 和 0.884。
结论
123I-MIBG 心肌闪烁显像术是预测可能的 DLB 向可能的 DLB 转化的良好预测因子。
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