大鼠松节油诱导炎症过程中皮质素转运蛋白和α2u球蛋白信使核糖核酸的活性

Transcortin and alpha 2u-globulin messenger RNA activities during turpentine-induced inflammation in the rat.

作者信息

Faict D, Verhoeven G, Mertens B, De Moor P

出版信息

J Steroid Biochem. 1985 Sep;23(3):243-6. doi: 10.1016/0022-4731(85)90400-5.

Abstract

Previously we have shown that the serum concentration of transcortin and alpha 2u-globulin markedly decreases during turpentine-induced inflammation. In the present study transcortin and alpha 2u-globulin mRNA from healthy rats and from animals with inflammation was translated in a rabbit reticulocyte lysate system. Female rats had higher levels of translatable transcortin mRNA than male animals and the level of mRNA for transcortin and alpha 2u-globulin decreased rapidly during inflammation. These results indicate that the sex difference in the serum level of transcortin and the changes in serum transcortin and alpha 2u-globulin during inflammation are mainly determined by differences in the mRNAs in the liver.

摘要

此前我们已经表明，在松节油诱导的炎症过程中，皮质素结合蛋白和α2u球蛋白的血清浓度显著降低。在本研究中，来自健康大鼠和患有炎症动物的皮质素结合蛋白和α2u球蛋白mRNA在兔网织红细胞裂解液系统中进行翻译。雌性大鼠可翻译的皮质素结合蛋白mRNA水平高于雄性动物，并且在炎症过程中皮质素结合蛋白和α2u球蛋白的mRNA水平迅速下降。这些结果表明，皮质素结合蛋白血清水平的性别差异以及炎症过程中血清皮质素结合蛋白和α2u球蛋白的变化主要由肝脏中mRNA的差异决定。