[Comparison of the haemodynamic effects in man of the beta-adrenergic blocking substances Kö 1366 and practolol (author's transl)].

In 21 healthy male persons haemodynamic changes (heart rate, end-diastolic pulmonary artery pressure, training condition of heart, a so-called index of heart sufficiency and arterial blood pressure) at rest and during dynamic exercise were compared respectively before and after i.v. injection of 0.0375 mg/kg of the beta-adrenergic blocking drug K+5Ao 1366 [O-(2-hydroxy-3-(tert. butylamino)-propoxy)-benzonitril-hydrochloride], of 0.3 mg/kg practolol [4-(2-hydroxy-3-isopropylaminopropoxy)-acetanilide] and a placebo. According to the analysed parameters Kö 1366 has an essentially better beta-adrenergic blocking potency than practolol. Neither of the two substances has a negative inotropic effect or influences the arterial blood pressure.