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[他汀类药物与糖尿病风险]

[Statins and the risk of diabetes].

作者信息

Simonyi Gábor

机构信息

Szent Imre Egyetemi Oktatókórház Anyagcsere Központ Budapest Tétényi út 12-16. 1115.

出版信息

Orv Hetil. 2013 Oct 27;154(43):1691-5. doi: 10.1556/OH.2013.29732.

Abstract

Statins have a relevant role in decreasing cardiovascular mortality. Statins are effective in primary and secondary prevention. Recently, it has been suggested that statins may have a diabetogenic effect, because a moderate increase in the risk of newly developed diabetes mellitus was observed. The diabetogenic effect of statins is a group effect and it is dose-dependent, too. The effect of statins which lower the cardiovascular risk attenuates the risk of developing diabetes during statin therapy, too. Hence, statins remain the first line therapy of reaching LDL-cholesterol targets.

摘要

他汀类药物在降低心血管死亡率方面具有重要作用。他汀类药物在一级和二级预防中均有效。最近,有人提出他汀类药物可能具有致糖尿病作用,因为观察到新发生糖尿病的风险有适度增加。他汀类药物的致糖尿病作用是一种群体效应,且也呈剂量依赖性。他汀类药物降低心血管风险的作用在他汀类药物治疗期间也会降低患糖尿病的风险。因此,他汀类药物仍然是实现低密度脂蛋白胆固醇目标的一线治疗药物。

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