King's College London, Institute of Psychiatry, UK.
Eur Eat Disord Rev. 2013 Nov;21(6):500-6. doi: 10.1002/erv.2266.
Advances in the treatment of anorexia nervosa (AN) are most likely to arise from targeted, brain-directed treatments, such as repetitive transcranial magnetic stimulation (rTMS). We describe findings from two individuals with treatment-resistant AN who received 19-20 sessions of neuronavigated, high frequency rTMS, applied to the left dorsolateral prefrontal cortex.
Within-session measures assessed changes pre-rTMS, post-rTMS in subjective eating disorder (ED) experiences. Weight, ED symptoms and mood were assessed pre-treatment, post-treatment and at 1 month follow-up.
In both cases, there was improvement in ED symptomatology and mood after 19-20 sessions of neuronavigated rTMS, and these changes persisted or continued to improve at follow-up. Within sessions, Patient A demonstrated a consistent reduction in subjective ED experiences, and Patient B a reduction in some ED related experiences.
These findings suggest that rTMS has potential as an adjunct to the treatment of AN and deserves further study.
治疗神经性厌食症 (AN) 的进展很可能源于有针对性的、针对大脑的治疗，如重复经颅磁刺激 (rTMS)。我们描述了两名接受经颅磁刺激治疗的难治性 AN 患者的发现，该治疗应用于左背外侧前额叶皮层，共进行了 19-20 次。
治疗过程中的评估包括治疗前、治疗后和 1 个月随访时主观进食障碍 (ED) 体验的变化。在治疗前、治疗后和 1 个月随访时评估体重、ED 症状和情绪。
在这两种情况下，经过 19-20 次神经导航 rTMS 治疗后，ED 症状和情绪均有改善，这些改善在随访时持续或继续改善。在治疗过程中，患者 A 表现出主观 ED 体验持续减少，而患者 B 则表现出一些与 ED 相关的体验减少。
这些发现表明 rTMS 有作为 AN 辅助治疗的潜力，值得进一步研究。
