乙醛酸 1 在肝细胞癌中上调，对 HCC 细胞增殖至关重要。
Glyoxalase 1 is up-regulated in hepatocellular carcinoma and is essential for HCC cell proliferation.
机构信息
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, 220 Handan Road, Shanghai, 200433, People's Republic of China,
出版信息
Biotechnol Lett. 2014 Feb;36(2):257-63. doi: 10.1007/s10529-013-1372-6. Epub 2013 Oct 25.
Glyoxalase 1 (Glo1), belonging to the glyoxalase system, participates in the detoxification of methylglyoxal (MG), a byproduct of glycolysis. Glo1 is associated with the progression of many human malignancies. However, the role of Glo1 in hepatocellular carcinoma (HCC) is unclear. We have discovered that the expression of Glo1 is up-regulated in HCC tissues compared with adjacent non-tumorous tissues, and knockdown of Glo1 expression by RNA interference significantly inhibited the proliferation of human HCC cell lines. Glo1 knockdown resulted in the accumulation of its cytotoxic substrate, MG. Overall, thus Glo1 might be essential for HCC progression and can be designated as a potential therapeutic target for HCC in the future.
醛糖酶 1（Glo1）属于醛糖酶系统，参与了甲基乙二醛（MG）的解毒，MG 是糖酵解的副产物。Glo1 与许多人类恶性肿瘤的进展有关。然而，Glo1 在肝细胞癌（HCC）中的作用尚不清楚。我们发现，与相邻的非肿瘤组织相比，Glo1 在 HCC 组织中的表达上调，并且通过 RNA 干扰敲低 Glo1 表达显著抑制了人 HCC 细胞系的增殖。Glo1 敲低导致其细胞毒性底物 MG 的积累。总的来说，因此 Glo1 可能对 HCC 的进展至关重要，并可能在未来被指定为 HCC 的潜在治疗靶点。
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