Honzel Nikki, Justus Timothy, Swick Diane
Medical Research Service, VA Northern California Health Care System, 150 Muir Road, Ste. 151-I, Martinez, CA, USA,
Cogn Affect Behav Neurosci. 2014 Jun;14(2):792-804. doi: 10.3758/s13415-013-0219-x.
Patients with posttraumatic stress disorder (PTSD) can show declines in working memory. A dual-task design was used to determine whether these impairments are linked to executive control limitations. Participants performed a Sternberg memory task with either one or four letters. In the dual-task condition, the maintenance period was filled with an arrow flanker task. PTSD patients were less accurate on the working memory task than were controls, especially in the dual-task condition. In the single-task condition, both groups showed similar patterns of brain potentials from 300 to 500 ms when discriminating old and new probes. However, when taxed with an additional task, the event-related potentials (ERPs) of the PTSD group no longer differentiated old and new probes. In contrast, interference resolution processes in both the single- and dual-task conditions of the flanker task were intact. The lack of differentiation in the ERPs reflects impaired working memory performance under more difficult, dual-task conditions. Exacerbated difficulty in performing a working memory task with concurrent task demands suggests a specific limitation in executive control resources in PTSD.
创伤后应激障碍(PTSD)患者的工作记忆可能会下降。采用双任务设计来确定这些损伤是否与执行控制限制有关。参与者执行一项包含一个或四个字母的斯特恩伯格记忆任务。在双任务条件下,维持期填充了箭头侧翼任务。PTSD患者在工作记忆任务上的准确性低于对照组,尤其是在双任务条件下。在单任务条件下,两组在辨别新旧探测刺激时,300至500毫秒的脑电模式相似。然而,当增加额外任务时,PTSD组的事件相关电位(ERP)不再能区分新旧探测刺激。相比之下,侧翼任务在单任务和双任务条件下的干扰解决过程都是完整的。ERP缺乏区分反映了在更困难的双任务条件下工作记忆表现受损。在有并发任务需求时执行工作记忆任务的难度加剧,表明PTSD患者在执行控制资源方面存在特定限制。