儿童生命早期的生长模式是否与 10 岁时的血清脂肪因子有关？
Is a child's growth pattern early in life related to serum adipokines at the age of 10 years?
机构信息
Helmholtz Zentrum München, German Research Centre for Environmental Health, Institute of Epidemiology I, Neuherberg, Germany.
University Hospital Leipzig, Faculty of Medicine, Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Leipzig, Germany.
出版信息
Eur J Clin Nutr. 2014 Jan;68(1):25-31. doi: 10.1038/ejcn.2013.213. Epub 2013 Oct 30.
BACKGROUND/OBJECTIVES: Growth parameters during infancy and early childhood might predict adipokine levels later in life. This study investigates the association between peak growth velocities, body mass index (BMI) and age at adiposity rebound (AR), with leptin and adiponectin levels at age 10 years.
SUBJECTS/METHODS: Peak height (PHV) and weight (PWV) velocities were calculated from height and weight measurements obtained between birth and age 2 years from 2880 children participating in the GINIplus (German Infant Nutritional Intervention plus environmental and genetic influences on allergy development) and LISAplus (Influences of Lifestyle-Related Factors on the Immune System and the Development of Allergies in Childhood plus Air Pollution and Genetics) birth cohorts. BMI and age at AR were calculated using BMI measurements between age 1.5 and 12 years. Blood samples were collected during a physical examination at age 10. Adiponectin and leptin levels were measured by radioimmunoassay. Linear regression models were fitted after adjustment for potential confounding factors and results are presented per interquartile range increase in the exposure.
RESULTS
Age at AR was negatively associated with leptin in males and females (percent difference β*: -41.71%; 95% confidence interval: (-44.34;-38.96) and β*: -43.22%; (-45.59; -40.75), respectively). For both males and females PWV (β*: 14.23%; (7.60; 21.26) and β*: 18.54%; (10.76; 26.87), respectively) and BMI at AR (β*: 63.08%; (55.04; 71.53) and β*: 67.02%; (59.30; 75.10), respectively) were positively associated with leptin levels. PHV showed a positive effect on leptin in females only (β*: 10.75%; (3.73; 18.25)). Growth parameters were not significantly associated with adiponectin except for age at AR among females (β: 0.75 ng/ml; (0.42; 1.09)) and PWV among males (β: 0.45 ng/ml; (0.11; 0.79)).
CONCLUSION
Growth patterns in early life may be associated with leptin levels at age 10 years.
背景/目的：婴儿期和幼儿期的生长参数可能预测生命后期的脂肪因子水平。本研究调查了峰值生长速度、体重指数（BMI）和肥胖反弹（AR）年龄与 10 岁时瘦素和脂联素水平之间的关系。
方法
从参加 GINIplus（德国婴儿营养干预以及环境和遗传因素对过敏发展的影响）和 LISAplus（生活方式相关因素对免疫系统和儿童期过敏发展的影响以及空气污染和遗传学）出生队列的 2880 名儿童的出生至 2 岁期间的身高和体重测量中计算出峰值身高（PHV）和体重（PWV）速度。使用 1.5 至 12 岁之间的 BMI 测量计算 BMI 和 AR 年龄。在 10 岁时的体检中采集血样。通过放射免疫测定法测量脂联素和瘦素水平。在调整了潜在混杂因素后，拟合线性回归模型，并按暴露量的四分位距增加呈现结果。
结果
在男性和女性中，AR 年龄与瘦素呈负相关（百分比差异β*：-41.71%；95%置信区间：（-44.34%；-38.96%）和β*：-43.22%；（-45.59%；-40.75%））。对于男性和女性，PWV（β*：14.23%；（7.60%；21.26%）和β*：18.54%；（10.76%；26.87%））和 AR 时的 BMI（β*：63.08%；（55.04%；71.53%）和β*：67.02%；（59.30%；75.10%））与瘦素水平呈正相关。仅在女性中，PHV 对瘦素有积极影响（β*：10.75%；（3.73%；18.25%））。除了女性的 AR 年龄（β：0.75ng/ml；（0.42%；1.09%））和男性的 PWV 年龄（β：0.45ng/ml；（0.11%；0.79%））外，生长参数与脂联素水平没有显著相关性。
结论
生命早期的生长模式可能与 10 岁时的瘦素水平有关。
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