Farlow Martin R, Schmitt Frederick, Aarsland Dag, Grossberg George T, Somogyi Monique, Meng Xiangyi
Department of Neurology, Indiana University School of Medicine, Indianapolis, Ind., USA.
Dement Geriatr Cogn Dis Extra. 2013 Sep 11;3(1):281-90. doi: 10.1159/000351861. eCollection 2013.
Greater understanding of differences in baseline impairment and disease progression in patients with Alzheimer's disease (AD) and Parkinson's disease dementia (PDD) may improve the interpretation of drug effects and the design of future studies.
This was a retrospective analysis of three randomized, double-blind rivastigmine databases (one in PDD, two in AD). Impairment on the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog), Alzheimer's Disease Cooperative Study-Activities of Daily Living (ADCS-ADL) scale, 10-item Neuropsychiatric Inventory (NPI-10) and the ADCS-Clinical Global Impression of Change (CGIC) was compared [standardized difference (Cohen's d), similar if <0.1].
Patients with AD or PDD had similar levels of impairment on the ADAS-cog and NPI-10. Scores on the ADCS-ADL scale (standardized difference = 0.47) and the ADAS-cog memory domain (total, 0.33; items, 0.10-0.58) were higher in AD; PDD patients were more impaired in the language (0.23) and praxis (0.34) domains. AD patients receiving placebo showed greater deterioration on the ADAS-cog (0.14) and improvement on the NPI-10 (0.11) compared with patients with PDD.
Differing patterns of impairment occur in AD and PDD.
深入了解阿尔茨海默病（AD）和帕金森病痴呆（PDD）患者的基线损伤及疾病进展差异，可能有助于更好地解读药物疗效并指导未来研究设计。
对三个随机、双盲的卡巴拉汀数据库进行回顾性分析（一个用于PDD，两个用于AD）。比较阿尔茨海默病评估量表认知分量表（ADAS-cog）、阿尔茨海默病协作研究日常生活活动量表（ADCS-ADL）、10项神经精神科问卷（NPI-10）以及ADCS临床总体变化印象量表（CGIC）的损伤情况[标准化差异（科恩d值），若<0.1则相似]。
AD或PDD患者在ADAS-cog和NPI-10上的损伤水平相似。AD患者在ADCS-ADL量表上的得分（标准化差异=0.47）以及ADAS-cog记忆领域得分（总分，0.33；各项目，0.10 - 0.58）更高；PDD患者在语言（0.23）和实践（0.34）领域损伤更严重。与PDD患者相比，接受安慰剂的AD患者在ADAS-cog上恶化更明显（0.14），而在NPI-10上改善更明显（0.11）。
AD和PDD存在不同的损伤模式。
Zotero 插件
