吉兰-巴雷综合征（GBS）中皮质运动神经元功能障碍？
Dysfunction of Corticomotoneurons in Guillain-Barré Syndrome (GBS)?
作者信息
Vucic Steve
机构信息
Department of Neurology, Westmead Hospital, Western Clinical School, University of Sydney, Wentworthville, NSW, 2145, Sydney, Australia. Email:
出版信息
Clin Med Case Rep. 2009 Oct 1;2:59-61. eCollection 2009.
Guillain-Barré syndrome (GBS) is characterized by acute and symmetric flaccid paraparesis and areflexia. Involvement of the central nervous system has been infrequently reported. In the current issue of Clinical Medicine: Case reports, an unusual case of GBS with asymmetric muscle weakness was reported. Corticomotoneuronal dysfunction was invoked as a possible cause for this neurological finding. Reversible blockade of voltage gated Na(+) channels resulting in conduction failure may be a possible pathophysiological mechanism.
吉兰-巴雷综合征（GBS）的特征是急性、对称性弛缓性下肢轻瘫和腱反射消失。中枢神经系统受累的报道较少。在本期《临床医学：病例报告》中，报道了1例罕见的GBS伴不对称肌无力病例。皮质运动神经元功能障碍被认为是这一神经学表现的可能原因。电压门控钠通道的可逆性阻断导致传导失败可能是一种潜在的病理生理机制。
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