Sec. of Nuclear Medicine, Dept. of Diagnostic Radiology, Yale University School of Medicine, 333 Cedar St., New Haven, CT 06510, USA.
J Nucl Med. 1979 Mar;20(3):248-51.
Desferoxamine (DEF) was administered intramuscularly (0.25 mg/g body weight) to mice harboring a Cloudman's melanoma S-91 3 hr before, simultaneously with, and 3 hr after i.v. injection of Ga-67 citrate (approximately 1 microCi/g body weight). Relative Ga-67 retention was compared with that in non-DEF controls at 24 hr. The chemical nature of Ga-67 excreted in urine following DEF was also studied in healthy mice. Desferoxamine administered 3 hr before Ga-67 had little effect on radiogallium localization; administration coincident with or 3 hr after radiogallium resulted in decreased retention at 24 hr. The effect was most profound when Ga-67 and DEF were administered simultaneously. In DEF-injected animals Ga-67 was excreted in the urine as a Ga-67-DEF complex. When DEF was administered 3 hr after Ga-67, there was a trend to greater tumor-to-blood activity ratios (.2 > p > .1).
去铁胺（DEF）在静脉注射 Ga-67 柠檬酸（约 1 微居里/克体重）前 3 小时、同时和后 3 小时肌肉内（0.25 毫克/克体重）给予携带 Cloudman 黑色素瘤 S-91 的小鼠。在 24 小时时，比较 Ga-67 的相对保留率与非 DEF 对照组。还在健康小鼠中研究了 DEF 给药后尿液中排出的 Ga-67 的化学性质。在 Ga-67 之前 3 小时给予去铁胺对放射性镓的定位几乎没有影响；在放射性镓同时或 3 小时后给药会导致 24 小时时的保留减少。当 Ga-67 和 DEF 同时给药时，效果最为明显。在给予 DEF 的动物中，Ga-67 作为 Ga-67-DEF 复合物从尿液中排出。当 DEF 在 Ga-67 后 3 小时给予时，肿瘤与血液的活性比值（.2 > p >.1）有增加的趋势。
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