一种新型内皮细胞特异性抗原的免疫组织化学和免疫化学特性
Immunohistochemical and immunochemical characterization of a new endothelial cell-specific antigen.
作者信息
Alles J U, Bosslet K
出版信息
J Histochem Cytochem. 1986 Feb;34(2):209-14. doi: 10.1177/34.2.2418100.
PMID:2418100
Abstract
A new monoclonal antibody (moab BW 200) of IgG3 kappa-isotype was generated which recognizes an epitope located on an antigen molecule restricted to human neoplastic and non-neoplastic endothelial cells. The molecular weight of the antigen was determined using immunoprecipitation analysis followed by SDS-PAGE. Despite its similar molecular weight to FVIII-RAG, the antigen detected by moab BW 200 was shown to be different from FVIII-RAG.
摘要
产生了一种新的IgG3 κ同种型单克隆抗体（moab BW 200），它识别位于一种抗原分子上的一个表位，该抗原分子仅限于人类肿瘤性和非肿瘤性内皮细胞。使用免疫沉淀分析继以SDS-PAGE测定该抗原的分子量。尽管其分子量与FVIII-RAG相似，但moab BW 200检测到的抗原显示与FVIII-RAG不同。
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