新生大鼠单谷氨酸钠对脑室周器官谷氨酸脱氢酶和氨基转移酶活性的影响。

Effect of neonatal monosodium glutamate on the activities of glutamate dehydrogenase and aminotransferases in the circumventricular organs of rat brain.

机构信息

Department of Neurology, SGPG Institute of Medical Sciences, P.O. Box 375, 226014, Lucknow, UP, India.

出版信息

Amino Acids. 1995 Dec;8(4):393-5. doi: 10.1007/BF00806557.

Abstract

Glutamate (Glu) the major amino acid in mammalian brain and most dietary proteins possesses neurotransmitter as well as neurotoxic properties. We administered monosodium glutamate (MSG) 4 mg/g bwt, sc on postnatal day (PND) 1 through 10 to rats on alternate days or daily and sacrificed them on PND 45 or PND 90 respectively. The activities of glutamate dehydrogenase and aminotransferases were evaluated in the circumventricular organs of brain. Results show that neonatal MSG produces alterations in glutamate metabolism in blood-brain-barrier deficient regions.

摘要

谷氨酸（Glu）是哺乳动物大脑中的主要氨基酸，也是大多数膳食蛋白质的组成部分，具有神经递质和神经毒性。我们通过 sc 给大鼠（体重 4mg/g）注射谷氨酸单钠（MSG），从出生后第 1 天到第 10 天，每隔一天或每天注射一次，然后分别在第 45 天或第 90 天处死。评估了脑室周围器官中谷氨酸脱氢酶和氨基转移酶的活性。结果表明，新生期 MSG 会改变血脑屏障缺陷区域的谷氨酸代谢。