补肾化痰、调神益智法治疗阿尔茨海默病的疗效观察。

Effect of reinforcing kidney-essence, removing phlegm, and promoting mental therapy on treating Alzheimer's disease.

机构信息

Key Laboratory of Senile Dementia, State Administration of Traditional Chinese Medicine of the People's Republic of China, Hubei University of Chinese Medicine, Wuhan 430065, China.

出版信息

J Tradit Chin Med. 2013 Aug;33(4):449-54. doi: 10.1016/s0254-6272(13)60147-8.

DOI:10.1016/s0254-6272(13)60147-8

PMID:24187864

Abstract

OBJECTIVE

To explore the mechanism of reinforcing kidney-essence, removing phlegm, and promoting mental therapy in treating Alzheimer's disease (AD).

METHODS

Sixty patients with AD in Wuhan No.1 Hospital of Traditional Chinese Medicine for Geriatrics from May 2009 to April 2011 were randomly divided into two groups, with 30 in each group. Patients in Bushenhuatanyizhi group (BHY group) took BHY instant granules (6 g, twice per day). Patients in the control group took piracetam (0.8 g, 3 times per day). There were twelve weeks in a course. Changes in the mini-mental state examination (MMSE) score and Activity of Daily Living Scale (ADL) score were analyzed before and after treatment.

RESULTS

MMSE scores in the two groups increased and ADL scores decreased after treatment, compared with those before treatment (both P < 0.05). The total effective rate was 86.67% in the BHY group (10 very effective, 13 effective, 7 non-responsive). The control group was 57.69% (5 very effective, 16 effective, 9 non-responsive) (P < 0.05). Superoxide dismutase levels were increased, lipid peroxide and triglyceride levels decreased after treatment in the BHY group as compared with the control group.

CONCLUSION

Reinforcing kidney-essence, removing phlegm, and promoting mental therapy can improve cognitive function and daily life of AD patients. The mechanism of the therapy might be related to improving blood fat, scavenging free radicals, and inhibiting lipid peroxides.

摘要

目的

探讨补肾化痰、益智开窍法治疗阿尔茨海默病（AD）的作用机制。

方法

将 2009 年 5 月至 2011 年 4 月在武汉市第一医院老年病科住院的 60 例 AD 患者随机分为两组，每组 30 例。补肾化痰益智组（BHY 组）给予 BHY 冲服剂（6 g，每日 2 次），对照组给予吡拉西坦（0.8 g，每日 3 次）。疗程均为 12 周。治疗前后分别分析简易智能状态检查表（MMSE）评分和日常生活能力量表（ADL）评分的变化。

结果

与治疗前比较，两组 MMSE 评分升高，ADL 评分降低（均 P<0.05）。BHY 组总有效率为 86.67%（10 例显效，13 例有效，7 例无效），对照组为 57.69%（5 例显效，16 例有效，9 例无效）（P<0.05）。与对照组比较，BHY 组治疗后超氧化物歧化酶水平升高，脂质过氧化物和三酰甘油水平降低。