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针对某些人类细菌病原体的传统草药植物和标准抗生素的抗菌筛选。

Antibacterial screening of traditional herbal plants and standard antibiotics against some human bacterial pathogens.

作者信息

Awan Uzma Azeem, Andleeb Saiqa, Kiyani Ayesha, Zafar Atiya, Shafique Irsa, Riaz Nazia, Azhar Muhammad Tehseen, Uddin Hafeez

机构信息

Biotechnology Lab, Department of Zoology, Azad Jammu and Kashmir University, Muzaffarabad, Pakistan.

出版信息

Pak J Pharm Sci. 2013 Nov;26(6):1109-16.

Abstract

Chloroformic and isoamyl alcohol extracts of Cinnnamomum zylanicum, Cuminum cyminum, Curcuma long Linn, Trachyspermum ammi and selected standard antibiotics were investigated for their in vitro antibacterial activity against six human bacterial pathogens. The antibacterial activity was evaluated and based on the zone of inhibition using agar disc diffusion method. The tested bacterial strains were Streptococcus pyogenes, Staphylococcus epidermidis, Klebsiella pneumonia, Staphylococcus aurues, Serratia marcesnces, and Pseudomonas aeruginosa. Ciprofloxacin showed highly significant action against K. pneumonia and S. epidermidis while Ampicillin and Amoxicillin indicated lowest antibacterial activity against tested pathogens. Among the plants chloroform and isoamyl alcohol extracts of C. cyminum, S. aromaticum and C. long Linn had significant effect against P. aeruginosa, S. marcesnces and S. pyogenes. Comparison of antibacterial activity of medicinal herbs and standard antibiotics was also recorded via activity index. Used medicinal plants have various phytochemicals which reasonably justify their use as antibacterial agent.

摘要

对锡兰肉桂、孜然芹、姜黄、阿魏以及选定的标准抗生素的氯仿提取物和异戊醇提取物进行了研究,以考察它们对六种人类细菌病原体的体外抗菌活性。采用琼脂纸片扩散法,根据抑菌圈评估抗菌活性。受试菌株为化脓性链球菌、表皮葡萄球菌、肺炎克雷伯菌、金黄色葡萄球菌、粘质沙雷氏菌和铜绿假单胞菌。环丙沙星对肺炎克雷伯菌和表皮葡萄球菌显示出高度显著的作用,而氨苄西林和阿莫西林对受试病原体的抗菌活性最低。在这些植物中,孜然芹、丁香和姜黄的氯仿提取物和异戊醇提取物对铜绿假单胞菌、粘质沙雷氏菌和化脓性链球菌有显著作用。还通过活性指数记录了药用植物和标准抗生素抗菌活性的比较。所使用的药用植物含有多种植物化学物质,这合理地证明了它们作为抗菌剂的用途。

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