[γ-羟基丁酸锂对家兔脑内5-羟色胺及5-羟吲哚乙酸含量的影响]
[Effect of lithium oxybutyrate on the serotonin and 5-hydroxyindoleacetic acid content in the brain of rabbits].
作者信息
Saratikov A S, Fisanova L L, Zamoshchina T A, Sakharova S A
出版信息
Biull Eksp Biol Med. 1986 Mar;101(3):312-5.
Single administration of lithium hydroxybutyrate (10 mg/kg) to rabbits decreased serotonin and 5-hydroxyindoleacetic acid (5-HIAA) content in the caudate nucleus. The drug administration for 8 days is accompanied by mediator accumulation in the cortex, caudate nucleus, tonsils, hypothalamus, thalamus, and midbrain with parallel reduction in 5-HIAA level in these structures. 15 days of lithium hydroxybutyrate administration lead to the increase of serotonin and 5-HIAA concentration, while 28 days of administration reduced the content of mediator and its metabolite.
给兔子单次注射羟基丁酸锂（10毫克/千克）会降低尾状核中血清素和5-羟吲哚乙酸（5-HIAA）的含量。连续8天给药该药物会伴随着介质在皮质、尾状核、扁桃体、下丘脑、丘脑和中脑的积累，同时这些结构中的5-HIAA水平会相应降低。连续15天注射羟基丁酸锂会导致血清素和5-HIAA浓度升高，而连续28天给药则会降低介质及其代谢物的含量。
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