Twenty-four hour blood glucose profiles during insulin and insulin plus aprotinin subcutaneous administration in type I diabetes.

Twenty-four hour glucose levels were measured in nineteen insulin treated type I diabetics both during insulin plus aprotinin treatments and insulin by itself. Aprotinin--a proteinase inhibitor agent--administered together with insulin (10.000 KIU for every 10 U.I. insulin) did not influence the effect of insulin on blood glucose levels. These findings do not support the hypothesis that the administration of aprotinin together with insulin can be clinically useful in conventional insulin treated diabetic patients.