Silva Clarice Lima Álvares da, Lima-Costa Maria Fernanda, Firmo Josélia Oliveira Araújo, Peixoto Sérgio Viana
Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Brasil.
Cad Saude Publica. 2013 Nov;29(11):2241-50. doi: 10.1590/0102-311x00183712.
The aim of this study was to examine the influence of low hemoglobin (Hb) and anemia on mortality in the elderly in a ten-year follow-up (1997-2007). Among the 1,742 elderly participants in the baseline cohort from Bambuí, Minas Gerais State, Brazil, 1,322 (82.3%) were followed for an average of 8.9 years. Probability of survival was estimated by Kaplan-Meier and Cox's proportional hazard ratios (HR), and confidence intervals (95%CI) were used, considering potential confounders. Anemia and low Hb (lowest tertile) were associated with increased risk of death (HR = 2.63, 95%CI: 1.83-3.76 and HR = 1.38, 95%CI: 1.07-1.79, respectively). The results show that anemia or low Hb (regardless of a diagnosis of anemia) should be interpreted and managed as independent determinants of mortality in this elderly population.
本研究的目的是在一项为期十年的随访(1997 - 2007年)中,考察低血红蛋白(Hb)和贫血对老年人死亡率的影响。在巴西米纳斯吉拉斯州班布伊基线队列的1742名老年参与者中,1322名(82.3%)被随访了平均8.9年。采用Kaplan - Meier法和Cox比例风险比(HR)估计生存概率,并考虑潜在混杂因素使用95%置信区间(95%CI)。贫血和低Hb(最低三分位数)与死亡风险增加相关(HR分别为2.63,95%CI:1.83 - 3.76和HR为1.38,95%CI:1.07 - 1.79)。结果表明,在该老年人群中,贫血或低Hb(无论是否诊断为贫血)都应被视为死亡率的独立决定因素进行解读和管理。