Ferede Getachew, Wondimeneh Yitayih
School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, P,O, Box 196, Gondar, Ethiopia.
BMC Hematol. 2013 Aug 9;13(1):8. doi: 10.1186/2052-1839-13-8.
Anaemia is a common complication of infection with the human immunodeficiency virus (HIV) and may have various causes. The aim of this study was to determine the prevalence and related factors of anemia in HAART-naive HIV positive Patients.
A retrospective study was conducted on HAART naive HIV positive patients at the Gondar University Hospital between September 2011 and August 2012. Socio-demographic and immunohematological (hemoglobin and CD4+ T cells) data were collected carefully from the existing ART logbook and patient follow up cards. Anaemia was defined according to the WHO criteria.
The overall prevalence of anaemia was 138 (35%). Female HAART naive HIV positive patients had significantly (P < 0.05) higher prevalence of anaemia than males (62% Vs 38%). The prevalence of anaemia at different CD4 level was; 6 (4%) with CD4 count greater than 500 cells/μL, 18 (13%) with a CD4 count of 350-500 cells/μL, 37 (27%) with a CD4 count of 200-349 cells/μL, 44 (32%) with a CD4 count of 100-199 cells/μL, 14 (10%) with a CD4 count of 50-99 and 19 (14%) with CD4 count of less than 50 cells/μL.
Our findings showed that one-third of HAART naïve HIV positive patients were anaemic and the increase in prevalence of anaemia with decreased CD4 cell count was statistically significant. Therefore, early diagnosis and treatment of anaemia in these patients are essential.
贫血是人类免疫缺陷病毒（HIV）感染的常见并发症，可能有多种原因。本研究的目的是确定未接受高效抗逆转录病毒治疗（HAART）的HIV阳性患者贫血的患病率及相关因素。
对2011年9月至2012年8月在贡德尔大学医院未接受HAART的HIV阳性患者进行回顾性研究。从现有的抗逆转录病毒治疗日志和患者随访卡中仔细收集社会人口统计学和免疫血液学（血红蛋白和CD4 + T细胞）数据。根据世界卫生组织标准定义贫血。
贫血的总体患病率为138例（35%）。未接受HAART的女性HIV阳性患者贫血患病率显著高于男性（P < 0.05）（62%对38%）。不同CD4水平的贫血患病率分别为：CD4计数大于500个细胞/μL时为6例（4%），CD4计数为350 - 500个细胞/μL时为18例（13%），CD4计数为200 - 349个细胞/μL时为37例（27%），CD4计数为100 - 199个细胞/μL时为44例（32%），CD4计数为50 - 99个细胞/μL时为14例（10%），CD4计数小于50个细胞/μL时为19例（14%）。
我们的研究结果表明，三分之一未接受HAART的HIV阳性患者患有贫血，且贫血患病率随CD4细胞计数降低而增加，差异有统计学意义。因此，对这些患者进行贫血的早期诊断和治疗至关重要。
