植物内生真菌 Pestalotiopsis fici 中的 2H-吡喃-2-酮和 2H-呋喃-2-酮衍生物。

2H-pyran-2-one and 2H-furan-2-one derivatives from the plant endophytic fungus Pestalotiopsis fici.

机构信息

State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, P. R. China (phone: +86-10-64806153).

出版信息

Chem Biodivers. 2013 Nov;10(11):2007-13. doi: 10.1002/cbdv.201200361.

DOI:10.1002/cbdv.201200361

PMID:24243609

Abstract

Two new α-pyrones (=2H-pyran-2-ones), ficipyrones A and B (1 and 2, resp.), and two new α-furanones (=2H-furan-2-ones), ficifuranones A and B (3 and 4, resp.), together with three known metabolites, antibiotic F 0368 (5), hydroxyseiridin (6), and hydroxyisoseiridin (7), were isolated from solid cultures of the plant endophytic fungus Pestalotiopsis fici. Their structures were elucidated primarily by NMR spectroscopy, and the absolute configuration of 1 was deduced from the circular-dichroism (CD) data. Compound 1 showed antifungal activity against the plant pathogen Gibberella zeae (CGMCC 3.2873) with an IC50 value of 15.9 μM.

摘要

从植物内生真菌 Pestalotiopsis fici 的固体培养物中分离得到两种新的α-吡喃酮（=2H-吡喃-2-酮），即 ficipyrones A 和 B（1 和 2），以及两种新的α-呋喃酮（=2H-呋喃-2-酮），ficifuranones A 和 B（3 和 4），此外还有三种已知代谢产物，抗生素 F 0368（5）、羟基西瑞啶（6）和羟基异西瑞啶（7）。它们的结构主要通过 NMR 光谱阐明，并且 1 的绝对构型是根据圆二色性（CD）数据推断出来的。化合物 1 对植物病原体禾谷镰刀菌（CGMCC 3.2873）表现出抗真菌活性，IC50 值为 15.9 μM。