氯沙坦对内皮祖细胞动员及内皮功能改善的作用。

Effects of losartan on the mobilization of endothelial progenitor cells and improvement of endothelial function.

作者信息

Tan Hong, Li Xiaoyan, Chen Wei, Chen Yingjian, Wei Xiuying, Yang Yan, Zhang Hongming, Jin Qun

机构信息

Department of Cardiology, the General Hospital of Ji'nan Military Region, Ji'nan 250031, Shangdong, China; e mail:

出版信息

Ann Clin Lab Sci. 2013 Fall;43(4):402-6.

PMID:24247796

Abstract

Through investigating the effect of the angiotensin receptor blocker (ARB) losartan on the number of endothelial progenitor cells (EPCs) and blood flow-mediated endothelium-dependent function (FMD) in the peripheral blood of patients with coronary heart disease (CHD), we found that FMD was improved and the number of circulating EPCs increased in the ARB treatment group (P <0.05). In addition, the increase in the number of EPCs was positively correlated with the improvement of FMD in the ARB treatment group (r = 0.52, P <0.01). These findings suggest that losartan may mobilize EPCs in the peripheral blood, improving endothelial function in CHD.

摘要

通过研究血管紧张素受体阻滞剂（ARB）氯沙坦对冠心病（CHD）患者外周血中内皮祖细胞（EPCs）数量及血流介导的内皮依赖性功能（FMD）的影响，我们发现氯沙坦治疗组的FMD得到改善，循环EPCs数量增加（P<0.05）。此外，氯沙坦治疗组中EPCs数量的增加与FMD的改善呈正相关（r = 0.52，P<0.01）。这些发现提示氯沙坦可能动员外周血中的EPCs，改善冠心病患者的内皮功能。