miR-200，人类癌症中一个新的明星 miRNA。
MiR-200, a new star miRNA in human cancer.
机构信息
Mitchell Cancer Institute, University of South Alabama, United States.
Department of Biological Sciences, University of Southern Mississippi Gulf Coast, United States.
出版信息
Cancer Lett. 2014 Mar 28;344(2):166-73. doi: 10.1016/j.canlet.2013.11.004. Epub 2013 Nov 19.
MicroRNAs (miRNAs) are a set of non-coding small RNA molecules in control of gene expression at posttranscriptional/translational level. They not only play crucial roles in normal developmental progress, but also are commonly dysregulated in human diseases, including cancer. MiR-200 is a family of tumor suppressor miRNAs consisting of five members, which are significantly involved in inhibition of epithelial-to-mesenchymal transition (EMT), repression of cancer stem cells (CSCs) self-renewal and differentiation, modulation of cell division and apoptosis, and reversal of chemoresistance. In this article, we summarize the latest findings with regard to the tumor suppressor signatures of miR-200 and the regulatory mechanisms of miR-200 expression. The collected evidence supports that miR-200 is becoming a new star miRNA in study of human cancer.
MicroRNAs (miRNAs) 是一组非编码的小 RNA 分子，在转录后/翻译水平控制基因表达。它们不仅在正常发育过程中起着至关重要的作用，而且在包括癌症在内的人类疾病中通常失调。miR-200 是一组肿瘤抑制 miRNA，由五个成员组成，它们显著参与抑制上皮-间充质转化 (EMT)、抑制癌症干细胞 (CSC) 的自我更新和分化、调节细胞分裂和凋亡以及逆转化学耐药性。本文总结了 miR-200 的肿瘤抑制特征和 miR-200 表达调控机制的最新发现。收集的证据表明，miR-200 正在成为人类癌症研究的一颗新星 miRNA。
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