健康与疾病状态下肾脏中的嘌呤能信号传导
Purinergic signalling in the kidney in health and disease.
作者信息
Burnstock Geoffrey, Evans Louise C, Bailey Matthew A
机构信息
Autonomic Neuroscience Centre, University College Medical School, Rowland Hill Street, London, NW3 2PF, UK,
出版信息
Purinergic Signal. 2014 Mar;10(1):71-101. doi: 10.1007/s11302-013-9400-5. Epub 2013 Nov 22.
The involvement of purinergic signalling in kidney physiology and pathophysiology is rapidly gaining recognition and this is a comprehensive review of early and recent publications in the field. Purinergic signalling involvement is described in several important intrarenal regulatory mechanisms, including tuboglomerular feedback, the autoregulatory response of the glomerular and extraglomerular microcirculation and the control of renin release. Furthermore, purinergic signalling influences water and electrolyte transport in all segments of the renal tubule. Reports about purine- and pyrimidine-mediated actions in diseases of the kidney, including polycystic kidney disease, nephritis, diabetes, hypertension and nephrotoxicant injury are covered and possible purinergic therapeutic strategies discussed.
嘌呤能信号传导在肾脏生理和病理生理中的作用正迅速得到认可，本文全面综述了该领域的早期和近期出版物。嘌呤能信号传导参与了几种重要的肾内调节机制，包括球管反馈、肾小球和球外微循环的自动调节反应以及肾素释放的控制。此外，嘌呤能信号传导影响肾小管各节段的水和电解质转运。本文涵盖了关于嘌呤和嘧啶介导的肾脏疾病作用的报告，包括多囊肾病、肾炎、糖尿病、高血压和肾毒物损伤，并讨论了可能的嘌呤能治疗策略。
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