青少年抑郁症负性情绪加工的功能连接
Functional connectivity of negative emotional processing in adolescent depression.
机构信息
University of California, San Francisco, Department of Psychiatry, 401 Parnassus Avenue, San Francisco, 94143, United States.
University of California, San Francisco, Department of Psychiatry, 401 Parnassus Avenue, San Francisco, 94143, United States.
出版信息
J Affect Disord. 2014 Feb;155:65-74. doi: 10.1016/j.jad.2013.10.025. Epub 2013 Oct 25.
BACKGROUND
The subgenual anterior cingulate cortex (sgACC) and its connected circuitry have been heavily implicated in emotional functioning in adolescent-onset major depressive disorder (MDD). While several recent studies have examined sgACC functional connectivity (FC) in depressed youth at rest, no studies to date have investigated sgACC FC in adolescent depression during negative emotional processing.
METHODS
Nineteen medication-naïve adolescents with MDD and 19 matched healthy controls (HCL) performed an implicit fear facial affect recognition task during functional magnetic resonance imaging (fMRI). We defined seeds in bilateral sgACC and assessed FC using the psychophysiological interaction method. We also applied cognitive behavioral modeling to estimate group differences in perceptual sensitivity in this task. Finally, we correlated connectivity strength with clinical data and perceptual sensitivity.
RESULTS
Depressed adolescents showed increased sgACC-amygdala FC and decreased sgACC-fusiform gyrus, sgACC-precuneus, sgACC-insula, and sgACC-middle frontal gyrus FC compared to HCL (p<0.05, corrected). Among the MDD, sgACC-precuneus FC negatively correlated with depression severity (p<0.05, corrected). Lastly, MDD adolescents exhibited poorer perceptual sensitivity in the task than HCL, and individual differences in perceptual sensitivity significantly correlated with sgACC FC and depression scores (p<0.05, corrected).
LIMITATIONS
Subjects were clinically homogenous, possibly limiting generalizability of the findings.
CONCLUSIONS
Adolescent depression is associated with biased processing of negative stimuli that may be driven by sgACC dysregulation and may possibly lead to an imbalance among intrinsic functional brain networks. This work also establishes the use of combining neuroimaging and cognitive behavioral modeling methods to investigate cognitive and neural differences between psychiatric and healthy populations.
背景
扣带回前部皮质亚区（sgACC）及其连接的回路在青少年发病的重度抑郁症（MDD）的情绪功能中起着重要作用。虽然最近有几项研究检查了抑郁青少年在静息状态下的 sgACC 功能连接（FC），但迄今为止，尚无研究调查青少年抑郁症患者在处理负性情绪时 sgACC 的 FC。
方法
19 名未经药物治疗的青少年 MDD 患者和 19 名匹配的健康对照者（HCL）在功能磁共振成像（fMRI）期间执行了内隐恐惧面部表情识别任务。我们在双侧 sgACC 定义种子，并使用心理生理交互方法评估 FC。我们还应用认知行为建模来估计该任务中感知敏感性的组间差异。最后，我们将连接强度与临床数据和感知敏感性相关联。
结果
与 HCL 相比，抑郁青少年的 sgACC-杏仁核 FC 增加，sgACC-梭状回、sgACC-楔前叶、sgACC-岛叶和 sgACC-额中回 FC 降低（p<0.05，校正）。在 MDD 中，sgACC-楔前叶 FC 与抑郁严重程度呈负相关（p<0.05，校正）。最后，MDD 青少年在任务中的感知敏感性较 HCL 差，并且感知敏感性的个体差异与 sgACC FC 和抑郁评分显著相关（p<0.05，校正）。
局限性
受试者在临床上具有同质性，可能限制了研究结果的普遍性。
结论
青少年抑郁症与对负性刺激的处理存在偏差，这可能是由 sgACC 调节异常引起的，并且可能导致内在功能脑网络之间的不平衡。这项工作还建立了使用神经影像学和认知行为建模方法相结合来研究精神病和健康人群之间的认知和神经差异。
Zotero 插件