从水/有机溶剂（W/O）乳液形成多层囊泡：理论与实践。
Formation of multilayered vesicles from water/organic-solvent (w/o) emulsions: theory and practice.
机构信息
Eli Lilly Research Laboratories, Indianapolis, Indiana, 46285.
出版信息
Pharm Res. 1986 Feb;3(1):23-34. doi: 10.1023/A:1016316730560.
PMID:24271353
Abstract
Multilayered liposome (MLV) formation from water/organic-solvent (W/O) emulsions was studied. A fundamental liposome population parameter, the E(ratio), was defined and used to estimate the bilayer number and water spacing in MLV liposomes. MLVs prepared from W/O emulsions have optimum drug entrapment at an emulsion-lipid/emulsion-water ratio of ∼0.33. Drug entrapment is typically 50 to 65% under these optimal conditions.
摘要
多层脂质体（MLV）由水/有机溶剂（W/O）乳液形成。定义了基本的脂质体群体参数 E（比值），用于估计 MLV 脂质体中的双层数和水间距。从 W/O 乳液制备的 MLVs 在乳液-脂质/乳液-水比约为 0.33 时具有最佳的药物包封率。在这些最佳条件下，药物包封率通常为 50%至 65%。
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