氨甲蝶呤聚谷氨酸盐在艾氏腹水癌细胞中的合成与潴留
Synthesis and retention of methotrexate polyglutamates in Ehrlich ascites carcinoma cells.
作者信息
Balińska M
出版信息
Drugs Exp Clin Res. 1986;12(6-7):551-4.
PMID:2427298
Abstract
The formation of methotrexate (MTX) polyglutamates in Ehrlich ascites carcinoma parental and 5-fluorodeoxy-uridine (FdUrd)-resistant cells was examined. The prolonged retention of methotrexate in noneffluxable-polyglutamate form and the pharmacological application of this process is discussed.
摘要
对艾氏腹水癌亲本细胞和5-氟脱氧尿苷（FdUrd）耐药细胞中氨甲蝶呤（MTX）多聚谷氨酸盐的形成进行了检测。讨论了氨甲蝶呤以不可外排的多聚谷氨酸盐形式的长期滞留及其药理学应用。
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